D-Fructose 1-phosphate
Based on 1 publication(s) in Google Scholar
D-Fructose 1-phosphate is a key intermediate metabolite in the fructose metabolic pathway. As a key signaling molecule linking fructose metabolism and glucose metabolic regulation, D-Fructose 1-phosphate acts as an allosteric modulator to counteract the inhibitory effect of the glucokinase-regulatory protein complex, thereby finely regulating the direction of hepatic glucose metabolism at the substrate level.
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- CAS No.: 15978-08-2
- Formula: C6H13O9P
- Molecular Weight:260.14
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) D-Fructose 1-phosphate
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Biological Activity
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Human Endogenous Metabolite |
D-Fructose 1-phosphate stimulates glucokinase activity in isolated hepatocytes from fed rats, with a half-maximal effective dose of 30 pmol/mg protein; glucagon attenuates this stimulatory effect[1].
D-Fructose 1-phosphate (1 mM) is a specific substrate of *Clostridioides difficile* fructose-1-phosphate kinase, with a Km value of 160 μM, and it is inhibited by sulfate and phosphate ions[1].
D-Fructose 1-phosphate directly dissociates the rat liver GKRP-GCK complex and relieves the GKRP-mediated inhibition of GCK[2].
D-Fructose 1-phosphate inhibits PKM2 in intestinal epithelial cells, thereby driving HIF-1α activation, hypoxic cell survival, villus elongation, and enhanced nutrient absorption[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 15978-08-2
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Molecular Weight 260.14
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Formula C6H13O9P
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SMILES
O[C@H](C(COP(O)(O)=O)=O)[C@@H]([C@@H](CO)O)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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BMC Microbiol
Unveiling the fructose metabolism system in Staphylococcus aureus: insights into the regulatory role of FruR and the FruRKT operon in bacterial fitness. [Abstract]2024 Jan 4;24(1):13. PMID: 38177984
Purity & Documentation
References
[1]. Davies DR, et al. Fructose 1-phosphate and the regulation of glucokinase activity in isolated hepatocytes. Eur J Biochem. 1990;192(2):283-289. [Content Brief]
[2]. Brouwers MCGJ, et al. Fructose 1-phosphate, an evolutionary signaling molecule of abundancy. Trends Endocrinol Metab. 2022;33(10):680-689. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
D-Fructose 1-phosphate Related Classifications
HY-112253 Related Classifications
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- D-Fructose 1-phosphate
- 15978-08-2
- Endogenous Metabolite
- glucokinase
- cardiovascular disease
- polycystic ovary syndrome
- pyruvate kinase M2 isoform
- hypoxia-inducible factor-1α
- glucokinase regulatory protein
- Clostridium difficile
- fructose 6-phosphate
- nonalcoholic fatty liver disease
- colorectal cancer
- Inhibitor
- inhibitor
- inhibit