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Cat. No.: HY-121625

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MK-785

MK-785 is a histidine decarboxylase inhibitor. MK-785 interacts with the cofactor Pyridoxal phosphate (HY-B1744). MK-785 reduces basal and gastrin-stimulated gastric acid secretion. MK-785 decreases the formation of stress ulcers induced by cold stress and restraint stress. MK-785 inhibits gastric histidine decarboxylase activity in brown rats. MK-785 can be used in studies related to stress ulcers.

For research use only. We do not sell to patients.

CAS No.: 16662-56-9
Formula: C₆H₁₀N₄O₂
Molecular Weight:170.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MK-785 Chemical Structure

CAS No.: 16662-56-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All Histamine Receptor Isoforms :

In Vitro

MK-785 (0.1-100 μM) inhibits purified fetal rat histidine decarboxylase in a concentration-dependent manner in vitro, with inhibition ranging from ~20% at 0.1 μM to ~95% at 100 μM in pooled human plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MK-785 (150 mg/kg; i.p.; single administration) maintains plasma drug concentrations for 4 h and inhibits histidine decarboxylase activity in rat stomach for 4 h, with the enzyme activity recovering at 10 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CD rats (female, 140-180 g, derived from Sprague-Dawley stock)^[1]
Dosage:

150 mg/kg
Administration:

i.p.; single dose
Result:

Reached peak plasma levels at 1 hour post-injection, maintained high levels for 4 hours, and declined to undetectable levels by 16 hours.
Highly inhibited gastric tissue histidine decarboxylase between 15 minutes and 4 hours post-injection, with enzyme activity returning to normal after 10 hours.

Chemical Information

CAS No. 16662-56-9
Molecular Weight 170.17
Formula C₆H₁₀N₄O₂
SMILES

O=C(C(CC1=CN=CN1)NN)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. KarlOtto Wustrack. Assay of histidine decarboxylase inhibitors inhuman plasms, rat plasma and rat gastric tissue. Yale University

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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MK-785

All Histamine Receptor Isoforms