2-Iodoacetamide-d4
Based on 1 Customer Validation
2-Iodoacetamide-d4 is the deuterium labeled 2-Iodoacetamide. 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics.
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- Purity: 98.74%
- CAS No.: 1219802-64-8
- 화학식: C2D4INO
- 분자량:188.99
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1219802-64-8
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Unlabeled Cas 144-48-9
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Appearance Solid
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분자량 188.99
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화학식 C2D4INO
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Color White to off-white
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SMILES
IC([2H])([2H])C(N([2H])[2H])=O
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Synonyms
Iodoacetamide-d4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (529.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Peter G Hains, et al. The Impact of Commonly Used Alkylating Agents on Artifactual Peptide Modification. J Proteome Resq. 2017 Sep 1;16(9):3443-3447. [Content Brief]
[3]. J J LALICH. Iodoacetamide induced gastric ulcers in rats. Proc Soc Exp Biol Med. 1962 Apr109:905-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.2913 mL | 26.4564 mL | 52.9129 mL | 132.2821 mL |
| 5 mM | 1.0583 mL | 5.2913 mL | 10.5826 mL | 26.4564 mL | |
| 10 mM | 0.5291 mL | 2.6456 mL | 5.2913 mL | 13.2282 mL | |
| 15 mM | 0.3528 mL | 1.7638 mL | 3.5275 mL | 8.8188 mL | |
| 20 mM | 0.2646 mL | 1.3228 mL | 2.6456 mL | 6.6141 mL | |
| 25 mM | 0.2117 mL | 1.0583 mL | 2.1165 mL | 5.2913 mL | |
| 30 mM | 0.1764 mL | 0.8819 mL | 1.7638 mL | 4.4094 mL | |
| 40 mM | 0.1323 mL | 0.6614 mL | 1.3228 mL | 3.3071 mL | |
| 50 mM | 0.1058 mL | 0.5291 mL | 1.0583 mL | 2.6456 mL | |
| 60 mM | 0.0882 mL | 0.4409 mL | 0.8819 mL | 2.2047 mL | |
| 80 mM | 0.0661 mL | 0.3307 mL | 0.6614 mL | 1.6535 mL | |
| 100 mM | 0.0529 mL | 0.2646 mL | 0.5291 mL | 1.3228 mL |
2-Iodoacetamide-d4 Related Classifications
HY-34477S1 Related Classifications
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