1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. PR-104

PR-104 

Cat. No.: HY-16405
Handling Instructions

PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-prodrug, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A.

For research use only. We do not sell to patients.

PR-104 Chemical Structure

PR-104 Chemical Structure

CAS No. : 851627-62-8

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Description

PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-prodrug, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A[1].

In Vitro

PR-104 (80 μM; 1 hour; SiHa cells) shows greater suppression of radiation-induced DNA single-strand breaks under hypoxic than aerobic conditions. PR-104 (100 μM; 1 hour; SiHa cells) results in phosphorylation of Ser139 of histone H2AX (gH2AX). PR-104 (0.266 mmol/kg; 18 h; SiHa cells) shows activity against hypoxic cells after irradiation. PR-104 varies in potency between cell lines, with the lowest IC50 (0.51 μmol/L) in H460 cells and highest (7.3 μmol/L) in PC3 prostate cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PR-104 (0.56 mmol/kg; i.v. or i.p.; 0~2 hours) makes the plasma area under the curve. PR-104 (0.23 mmol/kg; i.p.; 100 days) shows antitumor activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1nu/nu mice
Dosage: 0.56 mmol/kg (Pharmacokinetics Analysis)
Administration: I.v. or i.p.
Result: The plasma area under the curve.
Animal Model: CD1-Foxn1nu mice
Dosage: 0.23 mmol/kg
Administration: I.p.
Result: Showed antitumor activity.
Molecular Weight

579.27

Formula

C₁₄H₂₀BrN₄O₁₂PS

CAS No.
SMILES

O=C(NCCOP(O)(O)=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCOS(=O)(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PR-104PR104PR 104DNA Alkylator/Crosslinkerselectivehypoxia-activatedcross-linkingtumorxenograftnitrogenmustardpre-prodrugInhibitorinhibitorinhibit

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PR-104
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HY-16405
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