1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. Satraplatin

Satraplatin (Synonyms: BMS182751; BMY45594; JM216)

Cat. No.: HY-17576 Purity: 99.82%
Handling Instructions

Satraplatin is an alkylating agent, with potent antitumor effect.

For research use only. We do not sell to patients.

Satraplatin Chemical Structure

Satraplatin Chemical Structure

CAS No. : 129580-63-8

Size Price Stock Quantity
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Satraplatin is an alkylating agent, with potent antitumor effect.

In Vitro

Satraplatin needs to avoid light in the solution, and it is unstable in the alkaline state but stable in the acidic state.
Satraplatin has potent antitumor activity. Satraplatin combined with dichloroacetate (DCA) inhibits UMC-11 cells with an IC50 of 1.36 ± 0.11 μM[1]. Satraplatin also suppresses CDDP-resistant (KB-R) cells (IC50, 7.04 μM), and causes G2/M arrest in KB-R cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

500.28

Formula

C10H22Cl2N2O4Pt

CAS No.
SMILES

[Cl-][Pt+4]([O-]C(C)=O)([O-]C(C)=O)([Cl-])([NH3])[NH2]C1CCCCC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 10 mg/mL (19.99 mM; ultrasonic and adjust pH to 1 with HCl; DMSO can inactivate Satraplatin's activity)

Ethanol : < 1 mg/mL (insoluble; DMSO can inactivate Satraplatin's activity)

H2O : < 0.1 mg/mL (insoluble; DMSO can inactivate Satraplatin's activity)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9989 mL 9.9944 mL 19.9888 mL
5 mM 0.3998 mL 1.9989 mL 3.9978 mL
10 mM 0.1999 mL 0.9994 mL 1.9989 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Cells are harvested, counted and distributed to microtiter plates in 100 μL medium at a density of 1×104 cells/well. Appropriate dilutions of test compounds (Satraplatin, etc.) are added to a total volume of 200 μL/well and plates incubated under tissue culture conditions for four days. Stock solutions of the compounds are prepared in either 70% ethanol or DMSO and diluted more than 100-fold for the assays. Solvent controls are included in all tests. Dose response curves are obtained by assessing cell proliferation at twofold drug dilutions in triplicate and used for calculation of IC50 values. Cell growth is quantified using a modified tetrazolium dye assay (MTT) and by measurement of the reduced formazane dye at 450 nm wavelength (medium control set to 100% proliferation)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.82%

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Satraplatin
Cat. No.:
HY-17576
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