1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. Altretamine hydrochloride

Altretamine hydrochloride (Synonyms: ENT-50852 hydrochloride; RB-1515 hydrochloride; WR-95704 hydrochloride)

Cat. No.: HY-B0181A
Handling Instructions

Altretamine hydrochloride is an alkylating antineoplastic agent.

For research use only. We do not sell to patients.

Altretamine hydrochloride Chemical Structure

Altretamine hydrochloride Chemical Structure

CAS No. : 2975-00-0

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Description

Altretamine hydrochloride is an alkylating antineoplastic agent.

In Vitro

Altretamine hydrochloride is an antineoplastic agent[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Altretamine (100, 133 mg/kg, ip.) in combination with Irofulven, increases the antitumor effect in mice bearing MV522 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

246.74

Formula

C₉H₁₉ClN₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[1]

Mice[1]
Balb/c nu/nu 4 week old female mice weighing 18-22 g, receive s.c. injections of 8-10 million MV522 cells. Altretamine is administered i.p. three times a week for 3 weeks, starting on day 10 after tumor implantation. Tumor size is measured in two perpendicular diameters and tumor weight (TW) estimated according to the formula: w = [(width)2 × length/2]. Altretamine is prepared as stock solutions of 1-10 mg/mL in 40% DMSO/normal saline and diluted with 10% DMSO/normal saline as required[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Altretamine hydrochloride
Cat. No.:
HY-B0181A
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