2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. Altretamine

Altretamine  (Synonyms: ENT-50852; RB-1515; WR-95704)

Cat. No.: HY-B0181 Purity: 99.64%
COA Handling Instructions

Altretamine is an alkylating antineoplastic agent.

For research use only. We do not sell to patients.

Altretamine Chemical Structure

Altretamine Chemical Structure

CAS No. : 645-05-6

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 66 In-stock
Estimated Time of Arrival: December 31
500 mg USD 238 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Altretamine:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Altretamine

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Altretamine is an alkylating antineoplastic agent.

In Vitro

Altretamine is an antineoplastic agent[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Altretamine (100, 133 mg/kg, ip.) in combination with Irofulven, increases the antitumor effect in mice bearing MV522 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

210.28

Appearance

Solid

Formula

C9H18N6
CAS No.
SMILES

CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (39.61 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7556 mL 23.7778 mL 47.5556 mL
5 mM 0.9511 mL 4.7556 mL 9.5111 mL
10 mM 0.4756 mL 2.3778 mL 4.7556 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (3.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (3.95 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
Animal Administration
[1]

Mice[1]
Balb/c nu/nu 4 week old female mice weighing 18-22 g, receive s.c. injections of 8-10 million MV522 cells. Altretamine is administered i.p. three times a week for 3 weeks, starting on day 10 after tumor implantation. Tumor size is measured in two perpendicular diameters and tumor weight (TW) estimated according to the formula: w = [(width)2 × length/2]. Altretamine is prepared as stock solutions of 1-10 mg/mL in 40% DMSO/normal saline and diluted with 10% DMSO/normal saline as required[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Altretamine645-05-6ENT-50852 RB-1515 WR-95704ENT50852ENT 50852RB1515RB 1515RB-1515WR95704WR 95704WR-95704DNA Alkylator/CrosslinkerInhibitorinhibitorinhibit

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