1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. Altretamine

Altretamine (Synonyms: ENT-50852; RB-1515; WR-95704)

Cat. No.: HY-B0181 Purity: 99.61%
Handling Instructions

Altretamine is an alkylating antineoplastic agent.

For research use only. We do not sell to patients.

Altretamine Chemical Structure

Altretamine Chemical Structure

CAS No. : 645-05-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 216 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Altretamine is an alkylating antineoplastic agent.

In Vitro

Altretamine is an antineoplastic agent[1].

In Vivo

Altretamine (100, 133 mg/kg, ip.) in combination with Irofulven, increases the antitumor effect in mice bearing MV522 cells[1].

Clinical Trial
Molecular Weight

210.28

Formula

C₉H₁₈N₆

CAS No.

645-05-6

SMILES

CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (39.61 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7556 mL 23.7778 mL 47.5556 mL
5 mM 0.9511 mL 4.7556 mL 9.5111 mL
10 mM 0.4756 mL 2.3778 mL 4.7556 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (3.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (3.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Mice[1]
Balb/c nu/nu 4 week old female mice weighing 18-22 g, receive s.c. injections of 8-10 million MV522 cells. Altretamine is administered i.p. three times a week for 3 weeks, starting on day 10 after tumor implantation. Tumor size is measured in two perpendicular diameters and tumor weight (TW) estimated according to the formula: w = [(width)2 × length/2]. Altretamine is prepared as stock solutions of 1-10 mg/mL in 40% DMSO/normal saline and diluted with 10% DMSO/normal saline as required[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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KeyWords:

Altretamine | ENT-50852 | RB-1515 | WR-95704 | ENT50852 | ENT 50852 | RB1515 | RB 1515 | WR95704 | WR 95704 | DNA Alkylator/Crosslinker | Inhibitor | inhibitor | inhibit

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Altretamine
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