2-Methyl-5-acetylphenol
2-Methyl-5-acetylphenol is a hydroxylated methylacetophenone that exists in the aerial parts of Cannabis sativa subsp. sativa. 2-Methyl-5-acetylphenol exhibits strong binding affinity to HIPK2. 2-Methyl-5-acetylphenol cannot reverse MPP+ (1-methyl-4-phenyl-pyridinium ion)-induced neuronal cytotoxicity. 2-Methyl-5-acetylphenol can be used for Parkinson's disease research.
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- CAS No.: 33414-49-2
- 화학식: C9H10O2
- 분자량:150.17
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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HIPK2 |
2-Methyl-5-acetylphenol (Compound 9) (12.5-100 μM; treatment for 24 h) fails to reverse MPP+-induced cytotoxicity in SH-SY5Y cells at concentrations ranging from 12.5 to 100 μM; instead, it exacerbates such cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human neuroblastoma SH-SY5Y cells
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Concentration:12.5, 25, 50, 100 μM
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Incubation Time:24 h
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Result:Recorded cell viability of 97.83%, 99.78%, 98.17%, and 96.25% when applied alone at 12.5, 25, 50, and 100 μM, respectively.
Detected cell viability of 33.75%, 38.41%, 38.98%, and 39.27% when applied in combination with 1.8 mM MPP⁺ at 12.5, 25, 50, and 100 μM, respectively.
Calculated rescue effect of -24.29%, -13.84%, -12.56%, and -11.91% at 12.5, 25, 50, and 100 μM, respectively.
Chemical Information
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CAS No. 33414-49-2
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Appearance Solid
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분자량 150.17
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화학식 C9H10O2
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SMILES
CC1=C(C=C(C=C1)C(=O)C)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Methyl-5-acetylphenol Related Classifications
HY-W152736 Related Classifications
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