4-Methylpentanoic acid
Based on 1 publication(s) in Google Scholar
4-Methylpentanoic acid (Isocaproic Acid) is a short-chain fatty acid and a metabolite of 20 α-hydroxycholesterol (HY-12316) that can be detected in feces. The concentration of 4-Methylpentanoic acid is closely associated with several diseases, such as depression. 4-Methylpentanoic acid is also applicable to studies on cholesterol metabolism.
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- Purity: 99.15%
- CAS No.: 646-07-1
- 화학식: C6H12O2
- 분자량:116.16
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보관:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) 4-Methylpentanoic acid
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Biological Activity
4-Methylpentanoic acid (200 μg (carrier added post-incubation); 3 h) produced by incubation of 20α-hydroxycholesterol-22-14C with bovine adrenal homogenate supernatant, with yields of 17% and 20% in two separate experiments, confirming it as a metabolite in the cholesterol degradation pathway[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BDF1 mice (male); Sprague Dawley rats (13/sex/dose)[1]
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Dosage:500, 1000, 2000 mg/kg (genotoxicity); 10, 50, 250 mg/kg/day (repeated dose/reproductive/developmental toxicity)
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Administration:p.o.; single dose (genotoxicity); p.o.; daily; 41-53 days (female rats); p.o.; daily; 42 days (male rats)
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Result:Showed no statistically significant increase in the incidence of micronucleated polychromatic erythrocytes in bone marrow at any tested dose.
Chemical Information
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CAS No. 646-07-1
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Appearance Liquid (Density: 0.9392 g/cm3)
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분자량 116.16
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화학식 C6H12O2
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Color Colorless to light yellow
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SMILES
CC(C)CCC(O)=O
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Synonyms
Isocaproic acid
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
MNAM enhances Blautia abundance and modulates Th17/Treg balance to alleviate diabetes in T2DM mice. [Abstract]2024 Dec;230(Pt 2):116593. PMID: 39454734
용액&용해도
DMSO : 100 mg/mL (860.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (21.52 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (21.52 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Data Sheet (271 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 8.6088 mL | 43.0441 mL | 86.0882 mL | 215.2204 mL |
| 5 mM | 1.7218 mL | 8.6088 mL | 17.2176 mL | 43.0441 mL | |
| 10 mM | 0.8609 mL | 4.3044 mL | 8.6088 mL | 21.5220 mL | |
| 15 mM | 0.5739 mL | 2.8696 mL | 5.7392 mL | 14.3480 mL | |
| 20 mM | 0.4304 mL | 2.1522 mL | 4.3044 mL | 10.7610 mL | |
| 25 mM | 0.3444 mL | 1.7218 mL | 3.4435 mL | 8.6088 mL | |
| 30 mM | 0.2870 mL | 1.4348 mL | 2.8696 mL | 7.1740 mL | |
| 40 mM | 0.2152 mL | 1.0761 mL | 2.1522 mL | 5.3805 mL | |
| 50 mM | 0.1722 mL | 0.8609 mL | 1.7218 mL | 4.3044 mL | |
| 60 mM | 0.1435 mL | 0.7174 mL | 1.4348 mL | 3.5870 mL | |
| 80 mM | 0.1076 mL | 0.5381 mL | 1.0761 mL | 2.6903 mL | |
| 100 mM | 0.0861 mL | 0.4304 mL | 0.8609 mL | 2.1522 mL |
4-Methylpentanoic acid Related Classifications
HY-W015882 Related Classifications
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- 4-Methylpentanoic acid
- 646-07-1
- Isocaproic acid
- Drug Metabolite
- dermal sensitization
- local respiratory toxicity
- bovine adrenal supernatant
- 20α-hydroxycholesterol
- saturated branched carboxylic acid
- cholesterol
- reproductive toxicity
- bovine adrenal homogenate supernatant
- cholesterol degradation pathway
- adrenocorticosteroid precursors
- Inhibitor
- inhibitor
- inhibit