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Belvarafenib TFA

(Synonyms: HM95573 TFA; GDC-5573 TFA; RG6185 TFA)
6 Cited Publications
고객리뷰

Based on 6 publication(s) in Google Scholar

Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

  • CAS No.: 2443966-84-3
  • 화학식: C25H17ClF4N6O3S
  • 분자량:592.95
  • 보관:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Belvarafenib TFA Chemical Structure
    Belvarafenib TFA Chemical Structure
  • Experimental Validation Results for Belvarafenib TFA
  • Experimental Validation Results for Belvarafenib TFA
  • Experimental Validation Results for Belvarafenib TFA
  • Experimental Validation Results for Belvarafenib TFA
  • Experimental Validation Results for Belvarafenib TFA
CAS No.: 2443966-84-3
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RT-PCRWBApoptosis AnalysisIFIn Vivo Efficacy Study
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  • Apoptosis Analysis
  • IF
  • In Vivo Efficacy Study

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  • Belvarafenib TFA Chemical Structure
    Belvarafenib TFA Chemical Structure
    1/16
  • 1/16

    Belvarafenib TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 May 6;17(1):600. [Abstract]

    Customer Validation
     Fold change of MTHFD2 transcripts following indicated treatment in WM3406 cells (left) and MeWo cells (right) treated with INK128, Cobimetinib and Belvarafenib (25 nM).

  • 1/16

    Belvarafenib TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 May 6;17(1):600. [Abstract]

    Customer Validation
     Western blot analysis of the indicated proteins in WM3406 (left) and MeWo (right) cells with ATF4 knockdown or Belvarafenib (25 nM) plus Cobimetinib treatment.

  • 1/16

    Belvarafenib TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 May 6;17(1):600. [Abstract]

    Customer Validation
     Percent apoptosis detected in DMSO- or Belvarafenib plus Cobimetinib- or Belvarafenib (25 nM) plus Cobimetinib plus nucleosides-treated WM3406 or MeWo cells.

  • 1/16

    Belvarafenib TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 May 6;17(1):600. [Abstract]

    Customer Validation
     Representative images of WM3406 and MeWo cells following Belvarafenib plus Cobimetinib- or Belvarafenib (25 nM) plus Cobimetinib plus nucleosides-treated for 18 h and processed for γH2AX (green) immunofluorescence.

  • 1/16

    Belvarafenib TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 May 6;17(1):600. [Abstract]

    Customer Validation
     Tumor growth curve comparing MaNRAS1007 melanomas grown on C57BL/6N host mice with or without Belvarafenib (5 mg/kg, i.g.) plus Cobimetinib treatments.

  • Belvarafenib TFA