COX-2-IN-31
COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). COX-2-IN-31 also inhibits transmembrane hCA IX(Ki=48.9 nM) and hCA XII(Ki=5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity.
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- CAS No.: 3039955-76-2
- 화학식: C17H16N6O4S
- 분자량:400.41
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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COX-1 12.5 μM (IC50) |
COX-2 60 nM (IC50) |
COX-2-IN-31 (compound 7b) potently inhibits hCA IX and XII with Ki values in the nanomolar range(48.9 nM and 5.8 nM) in the Carbonic anhydrase inhibition assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
COX-2-IN-31 (10 mg/kg; oral gavage; single dose) results a significant reduction of paw height in Carrageenan (HY-125474)-induced rat paw edema assay[1].
COX-2-IN-31 (10 mg/kg; p.o; single dose) shows safety profile on the gastric tissues in male albino rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Acetic acid writhing test in mice[1]
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Dosage:10 mg/kg
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Administration:Oral gavage; single dose; 1 h.
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Result:Decreased the number of writhing responses of mouse conpared with control group.
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Animal Model:Carrageenan (HY-125474)-induced rat paw edema[1]
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Dosage:10 mg/kg
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Administration:Oral gavage:; single dose; 1-3h
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Result:Decreased the edema volume of mouse conpared with control group.
Chemical Information
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CAS No. 3039955-76-2
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분자량 400.41
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화학식 C17H16N6O4S
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SMILES
NC1=C(C=NN1C2=CC=C(C=C2)S(N)(=O)=O)C(N/N=C/C3=CC=C(C=C3)O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Ragab MA, et al. 4-(5-Amino-pyrazol-1-yl) benzene sulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Mar 15; 250:115180. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2-IN-31 Related Classifications
HY-149270 Related Classifications
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