CP-547632 TFA
Based on 2 publication(s) in Google Scholar
CP-547632 TFA is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 TFA is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs). CP-547632 TFA has antitumor efficacy.
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- Purity: 98.04%
- CAS No.: 2805804-54-8
- 화학식: C22H25BrF5N5O5S
- 분자량:646.43
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보관:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CP-547632 TFA
MoreAll VEGFR Isoforms
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Biological Activity
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VEGFR2 11 nM (IC50) |
FGFR 9 nM (IC50) |
CP-547632 TFA (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion, with an IC50 value of 6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Serum-deprived cells
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Concentration:1, 4, 16, 63, 250, 1000 nM
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Incubation Time:1 hours
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Result:Inhibited VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion.
CP-547632 TFA (oral; 50 mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for 12 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Athymic female mice (CD-1 nu/nu) bearing tumors (75-150 mm in size)[1]
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Dosage:6.25, 12.5, 25, 50, 100 mg/kg
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Administration:PO; daily; 10-24 days
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Result:Caused a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts.
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Animal Model:Female athymic mice bearing H-Ras tumor[1]
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Dosage:50 mg/kg
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Administration:Oral
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Result:A single oral dose of 50 mg/kg yielded plasma concentrations above 500 ng/ml for 12 hours.
Chemical Information
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CAS No. 2805804-54-8
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Appearance Solid
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분자량 646.43
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화학식 C22H25BrF5N5O5S
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Color Off-white to light yellow
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SMILES
FC(F)(C(O)=O)F.O=C(NC1=C(C(N)=O)C(OCC2=C(F)C=C(Br)C=C2F)=NS1)NCCCCN3CCCC3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Rep
2026 Jun 18;45(7):117576. PMID: 42313565 -
ACS Omega
Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]2024 Feb 28;9(10):11870-11882. PMID: 38496939
용액&용해도
DMSO : 150 mg/mL (232.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5470 mL | 7.7348 mL | 15.4696 mL | 38.6739 mL |
| 5 mM | 0.3094 mL | 1.5470 mL | 3.0939 mL | 7.7348 mL | |
| 10 mM | 0.1547 mL | 0.7735 mL | 1.5470 mL | 3.8674 mL | |
| 15 mM | 0.1031 mL | 0.5157 mL | 1.0313 mL | 2.5783 mL | |
| 20 mM | 0.0773 mL | 0.3867 mL | 0.7735 mL | 1.9337 mL | |
| 25 mM | 0.0619 mL | 0.3094 mL | 0.6188 mL | 1.5470 mL | |
| 30 mM | 0.0516 mL | 0.2578 mL | 0.5157 mL | 1.2891 mL | |
| 40 mM | 0.0387 mL | 0.1934 mL | 0.3867 mL | 0.9668 mL | |
| 50 mM | 0.0309 mL | 0.1547 mL | 0.3094 mL | 0.7735 mL | |
| 60 mM | 0.0258 mL | 0.1289 mL | 0.2578 mL | 0.6446 mL | |
| 80 mM | 0.0193 mL | 0.0967 mL | 0.1934 mL | 0.4834 mL | |
| 100 mM | 0.0155 mL | 0.0773 mL | 0.1547 mL | 0.3867 mL |
CP-547632 TFA Related Classifications
HY-13302C Related Classifications
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