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Cat. No.: HY-135618

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DHODH-IN-3

DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC₅₀ value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a K_i^app of 32 nM. DHODH-IN-3 has the potential for malaria treatment.

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CAS No.: 1148126-04-8
화학식: C₁₇H₁₃ClN₂O₂
분자량:312.75

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

DHODH-IN-3 Chemical Structure

CAS No.: 1148126-04-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50: 261 nM (HsDHODH)^[1]

All DNA/RNA Synthesis Isoforms :

In Vitro

DHODH-IN-3 (compound 3) show good inhibitory effects on HsDHODH with IC₅₀ value of 261 nM. It binds to HsDHODH with a K_i^app value of 32 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1148126-04-8
분자량 312.75
화학식 C₁₇H₁₃ClN₂O₂
SMILES

C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2)C=C1Cl)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.J Med Chem. 2009 May 14;52(9):2683-93. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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DHODH-IN-3

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

DHODH-IN-3 Related Classifications

HY-135618 Related Classifications