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Cat. No.: HY-184129A

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(E)-IDO1/TDO-IN-15

(E)-IDO1/TDO-IN-15 is an isomer of IDO1/TDO-IN-15 (HY-184129). IDO1/TDO-IN-15 is a dual IDO1/TDO inhibitor with an IDO1 IC₅₀ of 0.19 μM and a TDO IC₅₀ of 0.37 μM. (E)-IDO1/TDO-IN-15 is applicable to the research of cancer and Alzheimer's disease.

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CAS No.: 2414964-76-2
화학식: C₂₀H₁₃FN₂O₄
분자량:364.33

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Please store the product under the recommended conditions in the Certificate of Analysis.

(E)-IDO1/TDO-IN-15 Chemical Structure

CAS No.: 2414964-76-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

IDO1

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.02 μM Compound: 9a	Inhibition of IDO1 in human HeLa cells Inhibition of IDO1 in human HeLa cells	[PMID: 32247733]

In Vitro

(E)-IDO1/TDO-IN-15 (compound 9a) potently inhibits purified IDO1 enzyme with an IC₅₀ of 0.19 μM, exhibiting activity comparable to INCB024360 (HY-15689)^[1].
(E)-IDO1/TDO-IN-15 inhibits purified TDO enzyme with an IC₅₀ of 0.37 μM^[1].
(E)-IDO1/TDO-IN-15 potently inhibits IDO1 in HeLa cells with an IC₅₀ of 0.02 μM, exhibiting activity equivalent to INCB024360 and better than its enzymatic IDO1 inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2414964-76-2
분자량 364.33
화학식 C₂₀H₁₃FN₂O₄
SMILES

O=C1N2C(C(C3=CC(F)=CC=C32)=O)=NC4=CC=C(/C=C/C(OCC)=O)C=C41
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase. Bioorg Med Chem Lett. 2020;30(11):127159. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
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(E)-IDO1/TDO-IN-15

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

(E)-IDO1/TDO-IN-15 Related Classifications

HY-184129A Related Classifications