Imetit dihydrobromide
Based on 1 Customer Validation
Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.16
- CAS No.: 32385-58-3
- 화학식: C6H12Br2N4S
- 분자량:332.06
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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All Histamine Receptor Isoforms
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Biological Activity
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H3 Receptor 0.3 nM (Ki) |
H4 receptor 2.7 nM (Ki) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[4]
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Dosage:2.5, 5, 10 mg/kg
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Administration:i.p. (30 min before Apomorphine)
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Result:Reduced the licking response induced by Apomorphine.
Chemical Information
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CAS No. 32385-58-3
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Appearance Solid
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분자량 332.06
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화학식 C6H12Br2N4S
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Color White to light brown
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SMILES
NC(SCCC1=CN=CN1)=N.Br.Br
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Synonyms
VUF 8325 dihydrobromide; SKF 91105 dihydrobromide
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
H2O : 50 mg/mL (150.58 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Liu C, et al. Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. [Content Brief]
[2]. Ling P, et al. Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol. 2004 May;142(1):161-71. [Content Brief]
[3]. Garbarg M, et al. S-[2-(4-imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J Pharmacol Exp Ther. 1992 Oct;263(1):304-10. [Content Brief]
[4]. Farzin D, et al. Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rat. Eur J Pharmacol. 2000 Sep 15;404(1-2):169-74. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.0115 mL | 15.0575 mL | 30.1150 mL | 75.2876 mL |
| 5 mM | 0.6023 mL | 3.0115 mL | 6.0230 mL | 15.0575 mL | |
| 10 mM | 0.3012 mL | 1.5058 mL | 3.0115 mL | 7.5288 mL | |
| 15 mM | 0.2008 mL | 1.0038 mL | 2.0077 mL | 5.0192 mL | |
| 20 mM | 0.1506 mL | 0.7529 mL | 1.5058 mL | 3.7644 mL | |
| 25 mM | 0.1205 mL | 0.6023 mL | 1.2046 mL | 3.0115 mL | |
| 30 mM | 0.1004 mL | 0.5019 mL | 1.0038 mL | 2.5096 mL | |
| 40 mM | 0.0753 mL | 0.3764 mL | 0.7529 mL | 1.8822 mL | |
| 50 mM | 0.0602 mL | 0.3012 mL | 0.6023 mL | 1.5058 mL | |
| 60 mM | 0.0502 mL | 0.2510 mL | 0.5019 mL | 1.2548 mL | |
| 80 mM | 0.0376 mL | 0.1882 mL | 0.3764 mL | 0.9411 mL | |
| 100 mM | 0.0301 mL | 0.1506 mL | 0.3012 mL | 0.7529 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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