JAK2-IN-17
JAK2-IN-17 (compound 20) is a potent JAK2 allosteric inhibitor. JAK2-IN-17 inhibits full-length JAK2 and JAK2 V617F with IC50s of 160 and 130 nM, respectively. JAK2-IN-17 covalently modifies Lys677 in the pseudokinase domain.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C15H13FN6O6S2
- 분자량:456.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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FL JAK2 wt 160 nM (IC50) |
FL JAK2 V617F 130 nM (IC50) |
Chemical Information
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분자량 456.43
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화학식 C15H13FN6O6S2
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SMILES
NS(C1=CC=C(NC2=NN(C(C3=CC=CC(OS(F)(=O)=O)=C3)=O)C(N)=N2)C=C1)(=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK2-IN-17 Related Classifications
HY-179428 Related Classifications
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