Loxoprofen-d4
Loxoprofen-d4 is deuterium labeled Loxoprofen. Loxoprofen is a non-steroidal anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively.
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- 화학식: C15H14D4O3
- 분자량:250.33
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 68767-14-6
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Appearance Solid
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분자량 250.33
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화학식 C15H14D4O3
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Color White to off-white
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SMILES
O=C1C(C([2H])([2H])C([2H])([2H])C1)CC2=CC=C(C(C)C(O)=O)C=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : ≥ 100 mg/mL (399.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14(5):1201-1203. [Content Brief]
[3]. Paudel S, et al. Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators. Pharmaceutics. 2019;11(9):479. Published 2019 Sep 16. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9947 mL | 19.9736 mL | 39.9473 mL | 99.8682 mL |
| 5 mM | 0.7989 mL | 3.9947 mL | 7.9895 mL | 19.9736 mL | |
| 10 mM | 0.3995 mL | 1.9974 mL | 3.9947 mL | 9.9868 mL | |
| 15 mM | 0.2663 mL | 1.3316 mL | 2.6632 mL | 6.6579 mL | |
| 20 mM | 0.1997 mL | 0.9987 mL | 1.9974 mL | 4.9934 mL | |
| 25 mM | 0.1598 mL | 0.7989 mL | 1.5979 mL | 3.9947 mL | |
| 30 mM | 0.1332 mL | 0.6658 mL | 1.3316 mL | 3.3289 mL | |
| 40 mM | 0.0999 mL | 0.4993 mL | 0.9987 mL | 2.4967 mL | |
| 50 mM | 0.0799 mL | 0.3995 mL | 0.7989 mL | 1.9974 mL | |
| 60 mM | 0.0666 mL | 0.3329 mL | 0.6658 mL | 1.6645 mL | |
| 80 mM | 0.0499 mL | 0.2497 mL | 0.4993 mL | 1.2484 mL | |
| 100 mM | 0.0399 mL | 0.1997 mL | 0.3995 mL | 0.9987 mL |
Loxoprofen-d4 Related Classifications
HY-B0578S Related Classifications
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