Multi-target kinase-IN-6
Multi-target kinase-IN-6 is a Multiple target kinase inhibitor. Multi-target kinase-IN-6 can inhibit cardiac RyR2- and NaV1.5-channels but stimulate SERCA2a pump activity. Multi-target kinase-IN-6 can be used for the research of cardiovascular disease, such as heart failure.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C26H36BN3O3S
- 분자량:481.46
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All Calcium Channel Isoforms
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Biological Activity
Multi-target kinase-IN-6 (Compound 12) (25 μM, 24 h) inhibits RyR2-mediated Ca2+ leakage in HEK-293 RyR2 R-CEPIA1er cells[1].
Multi-target kinase-IN-6 (1.1 μM, 2 h) activates sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) in HL-1 cardiomyocytes[1].
Multi-target kinase-IN-6 (2.3 nM, 10 mins) significantly enhances the ATPase activity of SERCA2a in sarcoplasmic reticulum microsomal vesicles isolated from adult mouse ventricles[1].
Multi-target kinase-IN-6 (10 μM, 30 mins) inhibits NaV1.5-mediated Na+ influx in CHO NaV1.5 Duo cells[1].
Multi-target kinase-IN-6 (10 μM, 24 h) causes no significant cell death in HL-1 cardiomyocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 481.46
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화학식 C26H36BN3O3S
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SMILES
OC(C=C1/C=C/C[NH+](CCCCCCN2CCSC3=CC=C(C=C3C2)OC)[BH2-]C#N)=C(C=C1)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Multi-target kinase-IN-6 Related Classifications
HY-178344 Related Classifications
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