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SHP099 monohydrochloride

76 Cited Publications
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Based on 76 publication(s) in Google Scholar

SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM.

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  • Purity: 99.87%
  • CAS No.: 2200214-93-1
  • 화학식: C16H20Cl3N5
  • 분자량:388.72
  • 보관:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • SHP099 monohydrochloride Chemical Structure
    SHP099 monohydrochloride Chemical Structure
  • Experimental Validation Results for SHP099 monohydrochloride
  • Experimental Validation Results for SHP099 monohydrochloride
  • Experimental Validation Results for SHP099 monohydrochloride
  • Experimental Validation Results for SHP099 monohydrochloride
  • Experimental Validation Results for SHP099 monohydrochloride
  • Experimental Validation Results for SHP099 monohydrochloride
  • Experimental Validation Results for SHP099 monohydrochloride
CAS No.: 2200214-93-1
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  • SHP099 monohydrochloride Chemical Structure
    SHP099 monohydrochloride Chemical Structure
    1/16
  • 1/16

    SHP099 monohydrochloride purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2022 Sep 12;7(1):317. [Abstract]

    Customer Validation
     Assessment of indicated protein levels using western blotting in SKOV3 cells exposed to 0.5 µM elaiophylin for 24 h alone, or in combination with CHX (5 µM pretreatment for 4 h), U0126 (15 µM), SHP099 (30 µM), BAY293 (5 µM), respectively.

  • 1/16

    SHP099 monohydrochloride purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2022 Sep 12;7(1):317. [Abstract]

    Customer Validation
     SKOV3 cells were exposed to 0.5 µM elaiophylin alone for 36 h, or in combination with CHX (5 µM pretreatment for 4 h), U0126 (15 µM), SHP099 (30 µM), BAY293 (5 µM), respectively, and subject to enzymatic activity determination of CTSB.

  • 1/16

    SHP099 monohydrochloride purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2022 Sep 12;7(1):317. [Abstract]

    Customer Validation
     SHP099 (30 mg/kg/d). Representative images of tumor specimens stained with the specified antibody using immunohistochemical staining.

  • 1/16

    SHP099 monohydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Apr 1;10(1):1473. [Abstract]

    Customer Validation
     SHP099(10 μM; 24 h) inhibits IRS1-AP2 interaction in primary hepatocytes.

  • 1/16

    SHP099 monohydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2018 Oct;8(10):1237-1249. [Abstract]

    Customer Validation
     Immunoblots of whole cell lysates or GST-RBD-precipitated (RAS-GTP, KRASGTP and NRAS-GTP) lysates from PDAC cells treated with DMSO, SHP099 10 μM, AZD6244 1 μM, or both drugs for the times indicated.

  • 1/16

    SHP099 monohydrochloride purchased from MedChemExpress. Usage Cited in: Hepatology. 2018 Jul;68(1):333-348. [Abstract]

    Customer Validation
     Primary human HSCs are treated with SHP099 for 1 hour. PDGF-BB is added and cells are cultured for 12 additional hours. Whole cell lysates and EVs are examined by WB (n=6).

  • 1/16

    SHP099 monohydrochloride purchased from MedChemExpress. Usage Cited in: Open Biol. 2017 May;7(5):170066. [Abstract]

    Customer Validation
     Comparing the effects of SHP2 degradation and allosteric inhibition on Ras/MAPK signalling. (a) Human U2OS, A549, K-562 and MDA-MB-468 cells are treated with DMSO control or 1, 5 and 10 µM SHP099 for 2 h prior to lysis. Extracts (10 µg protein) are resolved by SDS-PAGE and transferred to nitrocellulose membranes, which are subjected to western blotting with the indicated antibodies. (b) Uninfected U2OS cells (WT) or cells infected with retroviruses encoding VHL, aCS3 and VHL-aCS3 are treated wit

  • SHP099 monohydrochloride