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Cat. No.: HY-110111A

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T2AA hydrochloride

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

T2AA hydrochloride is a non-peptide small molecule PCNA inhibitor T2 amino alcohol (T2AA) that lacks thyroid hormone activity. T2AA hydrochloride inhibits the interaction of PCNA/PIP-box peptide (IC50=~1 μM) and the interaction of PCNA with full-length p21 protein.

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CAS No.: 2138331-07-2
화학식: C₁₅H₁₆ClI₂NO₃
분자량:547.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

T2AA hydrochloride Chemical Structure

CAS No.: 2138331-07-2

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Chemical Information

CAS No. 2138331-07-2
분자량 547.55
화학식 C₁₅H₁₆ClI₂NO₃
SMILES

IC(C=C(C=C1I)C[C@H](N)CO)=C1OC2=CC=C(C=C2)O.Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Sci Adv

A genetic screen for modifiers of cohesin clustering identifies regulators of genome folding. [Abstract]

2026 Jan 30;12(5):eadx5130. PMID: 41616049
Environ Sci Technol

IodoFinder: Machine Learning-Guided Recognition of Iodinated Chemicals in Nontargeted LC-MS/MS Analysis. [Abstract]

2025 Mar 11;59(9):4530-4539. PMID: 40015982

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Punchihewa C, et al. Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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T2AA hydrochloride

2 Cited Publications

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Publications (2)
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T2AA hydrochloride

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) T2AA hydrochloride

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Publications (2)

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T2AA hydrochloride

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) T2AA hydrochloride

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Publications (2)

순도&문서

References

Calculators

Help & FAQs

T2AA hydrochloride Related Classifications

HY-110111A Related Classifications