Timolol hemihydrate
Based on 6 publication(s) in Google Scholar
Timolol (hemihydrate) is a β-blocker available for both topical and systemic administration. Timolol (hemihydrate) is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension and Timolol (hemihydrate) also has cardioprotective effect.
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- CAS No.: 91524-16-2
- 화학식: C13H24N4O3S.1/2H3O
- 분자량:325.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Publications Citing Use of MedChemExpress (MCE) Timolol hemihydrate
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
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β adrenergic receptor |
Timolol (hemihydrate) can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol (hemihydrate) can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats[3].
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Dosage:5 mg/kg
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Administration:Timolol (5 mg/kg daily for 12-week)
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Result:Showed cardioprotective effect.
Chemical Information
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CAS No. 91524-16-2
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분자량 325.43
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화학식 C13H24N4O3S.1/2H3O
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SMILES
O[C@@H](CNC(C)(C)C)COC1=NSN=C1N2CCOCC2.[1/2H2O]
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Synonyms
(S)-L-714,465 hemihydrate; MK 950 hemihydrate
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Adv Mater
Colloid-Forming Prodrug-Hydrogel Composite Prolongs Lower Intraocular Pressure in Rodent Eyes after Subconjunctival Injection. [Abstract]2025 Jan 6:e2419306. PMID: 39763100 -
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Protein Cell
Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy. [Abstract]2019 Mar;10(3):178-195. PMID: 29542010 -
Redox Biol
2024 Dec 21:79:103481. PMID: 39721495 -
Mater Today Bio
Transdermal delivery of timolol maleate using hydrogel microneedles for the treatment of infantile haemangiomas. [Abstract]2025 Apr 12:32:101752. PMID: 40290897 -
순도&문서
References
[1]. Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr [Content Brief]
[2]. E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22(1):152. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Timolol hemihydrate Related Classifications
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