country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-106918

Copy Link Print Information

Tivirapine

(Synonyms: R86183; TIBO R 86183)

Tivirapine (R86183) is a nonnucleoside HIV-1 RT inhibitor against HIV-1-induced cytopathic effects with an EC₅₀ value of 4 nM. Tivirapine inhibits the Yl8lC mutant of HIV-1 RT.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 137332-54-8
화학식: C₁₆H₂₀ClN₃S
분자량:321.87

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Tivirapine Chemical Structure

CAS No.: 137332-54-8

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Tivirapine (R86183) is a nonnucleoside HIV-1 RT inhibitor against HIV-1-induced cytopathic effects with an EC₅₀ value of 4 nM. Tivirapine inhibits the Yl8lC mutant of HIV-1 RT^[1].

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
C8166	CC₅₀	50 μM Compound: 8-CITIBO	Cytotoxicity against C8166 cells by MTT assay Cytotoxicity against C8166 cells by MTT assay	[PMID: 16279773]
C8166	EC₅₀	0.03 μM Compound: 8-ClTIBO	Antiviral activity against HIV1 3B infected human C8166 cells assessed as inhibition of syncytia formation by p24 antigen based assay Antiviral activity against HIV1 3B infected human C8166 cells assessed as inhibition of syncytia formation by p24 antigen based assay	[PMID: 19170521]
C8166	EC₅₀	0.03 μM Compound: 2 (8-CITIBO)	Concentration which produces a 50% survival of HIV-1 infected cells relative to uninfected control C8166 cells Concentration which produces a 50% survival of HIV-1 infected cells relative to uninfected control C8166 cells	[PMID: 11462972]
C8166	EC₅₀	0.03 μM Compound: 8-CITIBO	Inhibition of HIV1-3B replication in C8166 cells Inhibition of HIV1-3B replication in C8166 cells	[PMID: 16279773]
C8166	IC₅₀	50 μM Compound: 2 (8-CITIBO)	Concentration which results in 50% survival of uninfected untreated control C8166 cells (cytotoxicity of the compound) Concentration which results in 50% survival of uninfected untreated control C8166 cells (cytotoxicity of the compound)	[PMID: 11462972]
MT2	EC₅₀	14 nM Compound: 2, 8-Cl-TIBO	Antiviral activity against HIV-1 infected un MT2 cells assessed as virus-induced cytopathicity after 5 days by MTT assay Antiviral activity against HIV-1 infected un MT2 cells assessed as virus-induced cytopathicity after 5 days by MTT assay	[PMID: 23380374]
MT2	IC₅₀	>100 nM Compound: 2, 8-Cl-TIBO	Cytotoxicity against human MT2 cells after 5 days by MTT assay Cytotoxicity against human MT2 cells after 5 days by MTT assay	[PMID: 23380374]
MT4	EC₅₀	0.0043 μM Compound: 9, R86183	Antiviral activity against Human immunodeficiency virus 1 infected in human MT4 cells Antiviral activity against Human immunodeficiency virus 1 infected in human MT4 cells	[PMID: 19632850]
MT4	EC₅₀	4.6 nM Compound: 3	Effective concentration of the compound to inhibit HIV-1 replication in HIV-infected MT-4 cells Effective concentration of the compound to inhibit HIV-1 replication in HIV-infected MT-4 cells	[PMID: 15771411]
MT4	IC₅₀	0.0043 μM Compound: 6a	Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1 Concentration required for 50% protection of MT-4 cells against the cytopathic effect of HIV-1	[PMID: 7877144]

Chemical Information

CAS No. 137332-54-8
분자량 321.87
화학식 C₁₆H₂₀ClN₃S
SMILES

ClC(C1=C2N3C[C@@H](N(C1)C/C=C(C)\C)C)=CC=C2NC3=S
Synonyms

R86183; TIBO R 86183
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ding J, et al. Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors. Nat Struct Biol. 1995 May;2(5):407-15. [Content Brief]

[2]. Zhou Z, et al. Relative free energy of binding and binding mode calculations of HIV-1 RT inhibitors based on dock-MM-PB/GS. Proteins. 2004 Nov 15;57(3):493-503. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Tivirapine

All HIV Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Tivirapine Related Classifications

HY-106918 Related Classifications