TRIA-662-d3
Based on 1 Customer Validation
TRIA-662-d3 is the deuterium labeled TRIA-662. TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities.
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- Purity: 99.60%
- CAS No.: 1218993-18-0
- 화학식: C7H6D3ClN2O
- 분자량:175.63
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1218993-18-0
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Unlabeled Cas 1005-24-9
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Appearance Solid
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분자량 175.63
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화학식 C7H6D3ClN2O
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Color Off-white to light yellow
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SMILES
[2H]C([N+]1=CC=CC(C(N)=O)=C1)([2H])[2H].[Cl-]
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Synonyms
1-Methylnicotinamide-d3chloride
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
H2O : 100 mg/mL (569.38 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. A M Kolodziejczyk, et al. Nanomechanical sensing of the endothelial cell response to anti-inflammatory action of 1-methylnicotinamide chloride. Int J Nanomedicine. 2013;8:2757-67. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.6938 mL | 28.4689 mL | 56.9379 mL | 142.3447 mL |
| 5 mM | 1.1388 mL | 5.6938 mL | 11.3876 mL | 28.4689 mL | |
| 10 mM | 0.5694 mL | 2.8469 mL | 5.6938 mL | 14.2345 mL | |
| 15 mM | 0.3796 mL | 1.8979 mL | 3.7959 mL | 9.4896 mL | |
| 20 mM | 0.2847 mL | 1.4234 mL | 2.8469 mL | 7.1172 mL | |
| 25 mM | 0.2278 mL | 1.1388 mL | 2.2775 mL | 5.6938 mL | |
| 30 mM | 0.1898 mL | 0.9490 mL | 1.8979 mL | 4.7448 mL | |
| 40 mM | 0.1423 mL | 0.7117 mL | 1.4234 mL | 3.5586 mL | |
| 50 mM | 0.1139 mL | 0.5694 mL | 1.1388 mL | 2.8469 mL | |
| 60 mM | 0.0949 mL | 0.4745 mL | 0.9490 mL | 2.3724 mL | |
| 80 mM | 0.0712 mL | 0.3559 mL | 0.7117 mL | 1.7793 mL | |
| 100 mM | 0.0569 mL | 0.2847 mL | 0.5694 mL | 1.4234 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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