TRIA-662
Based on 1 Customer Validation
TRIA-662 (1-Methylnicotinamide chloride) is an endogenous metabolite. TRIA-662 shows antithrombotic and anti-inflammatory activities.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 1005-24-9
- Formula: C7H9ClN2O
- Molecular Weight:172.61
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
TRIA-662 (0.1-10 μM; 12 and 24 h) treatment shows polymerization of the G-actin[1].
TRIA-662 (0.05-0.2 μM; 1-24 h) shows anti-inflammatory activity in the endothelium[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HMECs
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Concentration:0.1 and 10 μM
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Incubation Time:12 and 24 hours
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Result:Showed polymerization of the G-actin, and strong, clearly visible, parallel F-actin fibers at 10 μM.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1005-24-9
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Appearance Solid
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Molecular Weight 172.61
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Formula C7H9ClN2O
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Color White to off-white
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SMILES
C[N+]1=CC=CC(C(N)=O)=C1.[Cl-]
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Synonyms
1-Methylnicotinamide chloride
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 110 mg/mL (637.27 mM; Need ultrasonic)
DMSO : 2 mg/mL (11.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (7.24 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (579.34 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.7934 mL | 28.9670 mL | 57.9341 mL | 144.8352 mL |
| 5 mM | 1.1587 mL | 5.7934 mL | 11.5868 mL | 28.9670 mL | |
| 10 mM | 0.5793 mL | 2.8967 mL | 5.7934 mL | 14.4835 mL | |
| H2O | 15 mM | 0.3862 mL | 1.9311 mL | 3.8623 mL | 9.6557 mL |
| 20 mM | 0.2897 mL | 1.4484 mL | 2.8967 mL | 7.2418 mL | |
| 25 mM | 0.2317 mL | 1.1587 mL | 2.3174 mL | 5.7934 mL | |
| 30 mM | 0.1931 mL | 0.9656 mL | 1.9311 mL | 4.8278 mL | |
| 40 mM | 0.1448 mL | 0.7242 mL | 1.4484 mL | 3.6209 mL | |
| 50 mM | 0.1159 mL | 0.5793 mL | 1.1587 mL | 2.8967 mL | |
| 60 mM | 0.0966 mL | 0.4828 mL | 0.9656 mL | 2.4139 mL | |
| 80 mM | 0.0724 mL | 0.3621 mL | 0.7242 mL | 1.8104 mL | |
| 100 mM | 0.0579 mL | 0.2897 mL | 0.5793 mL | 1.4484 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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