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Lanreotide acetate (Synonyms: BIM 23014 acetate)

Cat. No.: HY-P1959A Purity: 99.91%
Handling Instructions

Lanreotide acetate (BIM 23014 acetate) is a somatostatin analogue with antineoplastic activity. Lanreotide acetate can be used for carcinoid syndrome.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Lanreotide acetate Chemical Structure

Lanreotide acetate Chemical Structure

CAS No. : 2378114-72-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
5 mg USD 75 In-stock
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Lanreotide acetate (BIM 23014 acetate) is a somatostatin analogue with antineoplastic activity. Lanreotide acetate can be used for carcinoid syndrome[1][2].

In Vitro

Lanreotide acetate (BIM 23014 acetate) (24-48 hours; 100  nM; GH3 cells) combines with radiation increasing in apoptotic sub-G1 proportion[1].
Lanreotide acetate results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide acetate at doses of 1, 10, 100, and 1000 nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 (50% inhibition of cell growth) was 57 nM[1].
Lanreotide acetate inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro[2].

In Vivo

Lanreotide acetate (2.5-10mg/kg; s.c.; daily for 5 days) resluts in tumor growth inhibition[1].

Animal Model: Male nude mice, 8 weeks old and 20–25 g in body weight (GH3 tumor-bearing nude mice)[1]
Dosage:  2.5, 5, 10 mg/kg
Administration: Subcutaneous; daily for 5 days
Result: Produced tumor growth inhibition.
Clinical Trial
Molecular Weight

1156.38

Formula

C₅₆H₇₃N₁₁O₁₂S₂

CAS No.

2378114-72-6

Sequence

{d-2nal}-Cys-Tyr-{d-Trp}-Lys-Val-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)

Sequence Shortening

{d-2nal}-CY-{d-Trp}-KVCT-NH2 (Disulfide bridge: Cys2-Cys7)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Protect from light, stored under nitrogen
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

LanreotideBIM 23014BIM23014BIM-23014OtherstumorGH-secretingpituitaryadenomahormoneapoptosisGH3cellsInhibitorinhibitorinhibit

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Lanreotide acetate
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HY-P1959A
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