2. LJ001

LJ001 is a broad-spectrum and orally active antiviral agent. LJ001 exerts antiviral activities by binding to viral membranes. LJ001 inhibits TGEV and PDCoV infection. LJ001 decreases TGEV N and PDCoV N-protein expression.

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LJ001 Chemical Structure

LJ001 Chemical Structure

CAS No. : 851305-26-5

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LJ001 Related Antibodies

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Description

LJ001 is a broad-spectrum and orally active antiviral agent. LJ001 exerts antiviral activities by binding to viral membranes. LJ001 inhibits TGEV and PDCoV infection. LJ001 decreases TGEV N and PDCoV N-protein expression[1][2].

In Vitro

LJ001 (0.782- 200 μM; 24 h) shows no significant cytotoxicity with a CC50 value of 146.4 μM for ST cells[1].
LJ001 (12.5 µM; 12, 24 h) inhibits transmissible gastroenteritis virus (TGEV) and porcine deltacoronavirus (PDCoV) infection[1].
LJ001 (12.5 µM; 1, 6,12, 24 h) decreases the TGEV and PDCoV gene mRNA expression in ST cells[1].
LJ001 can inhibit the entry and spread of some enveloped viruses, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza, Ebola, arenaviruses and poxvi ruses[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LJ001 Related Antibodies

Cell Viability Assay[1]

Cell Line: ST cells
Concentration: 0.782, 1.563, 3.125, 6.25, 12.5, 25, 50, 100, 200 μM
Incubation Time: 24 h
Result: Showed slight cytotoxicity with a CC50 value of 146.4 μM.

Western Blot Analysis[1]

Cell Line: ST cells
Concentration: 12.5 µM
Incubation Time: 12, 24 h
Result: Decreased the expression of TGEV N protein and PDCoV N-protein at 24 h and markedly reduced TCID50 titers at 12 and 24 h.

RT-PCR[1]

Cell Line: ST cells
Concentration: 12.5 µM
Incubation Time: 1, 6, 12, 24 h
Result: Inhibited TGEV and PDCoV gene mRNA expression in a time-dependent manner.
In Vivo

LJ001 (20, 50 mg/kg; oral gavage or i.p.; daily for 7 days) shows no toxicity in mouse[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice[2]
Dosage: 20, 50 mg/kg
Administration: Oral gavage or i.p.; daily for 7 days
Result: Revealed no abnormalities except a slight elevation in serum cholesterol levels in the treated vs. vehicle control group.
Molecular Weight

327.42

Formula

C17H13NO2S2
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

S=C(N(CC=C)C/1=O)SC1=C/C(O2)=CC=C2C3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (305.42 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0542 mL 15.2709 mL 30.5418 mL
5 mM 0.6108 mL 3.0542 mL 6.1084 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (15.27 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0542 mL 15.2709 mL 30.5418 mL 76.3545 mL
5 mM 0.6108 mL 3.0542 mL 6.1084 mL 15.2709 mL
10 mM 0.3054 mL 1.5271 mL 3.0542 mL 7.6355 mL
15 mM 0.2036 mL 1.0181 mL 2.0361 mL 5.0903 mL
20 mM 0.1527 mL 0.7635 mL 1.5271 mL 3.8177 mL
25 mM 0.1222 mL 0.6108 mL 1.2217 mL 3.0542 mL
30 mM 0.1018 mL 0.5090 mL 1.0181 mL 2.5452 mL
40 mM 0.0764 mL 0.3818 mL 0.7635 mL 1.9089 mL
50 mM 0.0611 mL 0.3054 mL 0.6108 mL 1.5271 mL
60 mM 0.0509 mL 0.2545 mL 0.5090 mL 1.2726 mL
80 mM 0.0382 mL 0.1909 mL 0.3818 mL 0.9544 mL
100 mM 0.0305 mL 0.1527 mL 0.3054 mL 0.7635 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LJ001851305-26-5LJ 001LJ-001Inhibitorinhibitorinhibit

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