LysoFP-NO2 

LysoFP-NO2 is a turn-on fluorescent probe for carbon monoxide (CO) that localizes to the lysosome. In the presence of lysosomal CO, lysoFP-NO2 is transformed into lysoFP-NH2, which is highly fluorescent. LysoFP-NO2 is selective for CO over various reactive nitrogen, oxygen, and sulfur species. It displays excitation/emission maxima of 440/528 nm, respectively, and is not cytotoxic to HepG2 cells for up to five hours when used at a concentration of 30 μM.

355.34

C₁₈H₁₇N₃O₅

69408-75-9

Solid

Light brown to brown

O=C1N(CCN2CCOCC2)C(C3=CC([N+]([O-])=O)=CC4=CC=CC1=C34)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Dhara, et al. A new lysosome-targetable turn-on fluorogenic probe for carbon monoxide imaging in living cells. Anal. Chem. 90(4), 2933-2938 (2018).