NIAD-4
Based on 1 publication(s) in Google Scholar
NIAD-4 is a blood-brain barrier permeable fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM.
For research use only. We do not sell to patients.
- Purity: 98.52%
- CAS No.: 868592-56-7
- Formula: C18H10N2OS2
- Molecular Weight:334.43
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NIAD-4
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Biological Activity
NIAD-4 binds to amyloid aggregates, hinders its internal rotation, increases its fluorescence quantum yield and fluorescence intensity, thereby making it an effective tool for detecting amyloid. NIAD-4 can cross the blood-brain barrier, and used for amyloid fibrils imaging in brains due to its charge neutrality and low molecular weight. NIAD-4 exhibits an excitation wavelength of 475 nM and an emission wavelength of 610 nM[2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
625
475
Chemical Information
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CAS No. 868592-56-7
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Appearance Solid
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Molecular Weight 334.43
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Formula C18H10N2OS2
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Color Orange to reddish brown
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SMILES
N#C/C(C#N)=C/C1=CC=C(C2=CC=C(C3=CC=C(O)C=C3)S2)S1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 25 mg/mL (74.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9902 mL | 14.9508 mL | 29.9016 mL | 74.7541 mL |
| 5 mM | 0.5980 mL | 2.9902 mL | 5.9803 mL | 14.9508 mL | |
| 10 mM | 0.2990 mL | 1.4951 mL | 2.9902 mL | 7.4754 mL | |
| 15 mM | 0.1993 mL | 0.9967 mL | 1.9934 mL | 4.9836 mL | |
| 20 mM | 0.1495 mL | 0.7475 mL | 1.4951 mL | 3.7377 mL | |
| 25 mM | 0.1196 mL | 0.5980 mL | 1.1961 mL | 2.9902 mL | |
| 30 mM | 0.0997 mL | 0.4984 mL | 0.9967 mL | 2.4918 mL | |
| 40 mM | 0.0748 mL | 0.3738 mL | 0.7475 mL | 1.8689 mL | |
| 50 mM | 0.0598 mL | 0.2990 mL | 0.5980 mL | 1.4951 mL | |
| 60 mM | 0.0498 mL | 0.2492 mL | 0.4984 mL | 1.2459 mL |
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