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Cat. No.: HY-111263R

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NIAD-4 (Standard)

NIAD-4 (Standard) is the analytical standard of NIAD-4 (HY-111263). This product is intended for research and analytical applications. NIAD-4 is a blood-brain barrier permeable fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (K_i) of 10 nM.

For research use only. We do not sell to patients.

CAS No.: 868592-56-7
Formula: C₁₈H₁₀N₂OS₂
Molecular Weight:334.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NIAD-4 (Standard) Chemical Structure

CAS No.: 868592-56-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 868592-56-7
Molecular Weight 334.43
Formula C₁₈H₁₀N₂OS₂
SMILES

N#C/C(C#N)=C/C1=CC=C(C2=CC=C(C3=CC=C(O)C=C3)S2)S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kenneth T. Cheng, et al. [[5'-(4-Hydroxyphenyl)[2,2’-bithiophen]-5-yl]methylene]-propanedinitrile NIAD-4.

[2]. Brandenburg E, et al., Specific in situ discrimination of amyloid fibrils versus α-helical fibres by the fluorophore NIAD-4. Mol Biosyst. 2012 Feb;8(2):557-64. [Content Brief]

[3]. Bae S, et al. Torsion-dependent fluorescence switching of amyloid-binding dye NIAD-4[J]. Chemical Physics Letters, 2015, 633: 109-113.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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