868592-56-7
868592-56-7
Chemical Structure
NIAD-4
- CAS No.: 868592-56-7
- Formula:C18H10N2OS2
- Molecular Weight:334.43
IUPAC Name: 2-((5'-(4-hydroxyphenyl)-[2,2'-bithiophen]-5-yl)methylene)malononitrile
InChIKey: KLFRZDOQQDHVSS-UHFFFAOYSA-N
SMILES: N#C/C(C#N)=C/C1=CC=C(C2=CC=C(C3=CC=C(O)C=C3)S2)S1
Biological Activity: NIAD-4 is a blood-brain barrier permeable fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM[1].
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NIAD-4 | 98.52% | NIAD-4 is a blood-brain barrier permeable fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM. | ||||||||||||||||||||
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NIAD-4 (Standard) | ≥98% | NIAD-4 (Standard) is the analytical standard of NIAD-4 (HY-111263). This product is intended for research and analytical applications. NIAD-4 is a blood-brain barrier permeable fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (Ki) of 10 nM. | ||||||||||||||||||||
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Structural Analogs
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Similarity Score 0.66
HY-159005TDTM -
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HY-N2852α-Terthienylmethanol -
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HY-128145HSD17B13-IN-41 -
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HY-110201Estrogen receptor modulator 1 -
Similarity Score 0.59
HY-W677684Nurr1 agonist 2 -
Similarity Score 0.58
HY-W1126222,5-Di(pyridin-4-yl)thiophene -
Similarity Score 0.58
![2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl) methyl]thiophene Chemical Structure](//file.medchemexpress.com/product_pic/hy-i0182.gif)
HY-I01822-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl) methyl]thiophene -
Similarity Score 0.57
![[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol Chemical Structure](//file.medchemexpress.com/product_pic/hy-120654.gif)
HY-120654[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol -
Similarity Score 0.57
HY-I02072-(5-Iodo-2-methylbenzoyl)-5-(4-fluorophenyl)thiophene -
Explore the MedChemAI to find more analogs
![2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl) methyl]thiophene Chemical Structure](http://file.medchemexpress.com/product_pic/hy-i0182.gif)
![[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol Chemical Structure](http://file.medchemexpress.com/product_pic/hy-120654.gif)
