69408-75-9
Chemical Structure
LysoFP-NO2
- CAS No.: 69408-75-9
- Formula:C18H17N3O5
- Molecular Weight:355.34
IUPAC Name: 2-(2-morpholinoethyl)-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione
InChIKey: MQBIIGAYEJQXCC-UHFFFAOYSA-N
SMILES: O=C1N(CCN2CCOCC2)C(C3=CC([N+]([O-])=O)=CC4=CC=CC1=C34)=O
Biological Activity: LysoFP-NO2 is a turn-on fluorescent probe for carbon monoxide (CO) that localizes to the lysosome. In the presence of lysosomal CO, lysoFP-NO2 is transformed into lysoFP-NH2, which is highly fluorescent. LysoFP-NO2 is selective for CO over various reactive nitrogen, oxygen, and sulfur species. It displays excitation/emission maxima of 440/528 nm, respectively, and is not cytotoxic to HepG2 cells for up to five hours when used at a concentration of 30 μM.
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LysoFP-NO2 | 98.2% | LysoFP-NO2 is a turn-on fluorescent probe for carbon monoxide (CO) that localizes to the lysosome. In the presence of lysosomal CO, lysoFP-NO2 is transformed into lysoFP-NH2, which is highly fluorescent. LysoFP-NO2 is selective for CO over various reactive nitrogen, oxygen, and sulfur species. It displays excitation/emission maxima of 440/528 nm, respectively, and is not cytotoxic to HepG2 cells for up to five hours when used at a concentration of 30 μM. | ||||||||||||||||||||
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