1. MAPK/ERK Pathway
  2. MAP4K
  3. MAP4K4-IN-3

MAP4K4-IN-3 

Cat. No.: HY-125012 Purity: 99.13%
Handling Instructions

MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent.

For research use only. We do not sell to patients.

MAP4K4-IN-3 Chemical Structure

MAP4K4-IN-3 Chemical Structure

CAS No. : 1811510-58-3

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Based on 1 publication(s) in Google Scholar

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Description

MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1].

IC50 & Target[1]

MAP4K4

14.9 nM (IC50)

In Vitro

MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic agents[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oral dosing in telemetered rats for 5 days with MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) results in a number of adverse effects. Substantial weight losses (7%) and body temperature increases (0.4°C) relative to controls are observed over the course of the study. For cardiovascular end points, maximal heart rate increases of 25 bpm, relative to controls, are induced by treatment with MAP4K4-IN-3[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

297.74

Formula

C₁₅H₁₂ClN₅

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (33.59 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3586 mL 16.7932 mL 33.5864 mL
5 mM 0.6717 mL 3.3586 mL 6.7173 mL
10 mM 0.3359 mL 1.6793 mL 3.3586 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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MAP4K4-IN-3
Cat. No.:
HY-125012
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