1. MAPK/ERK Pathway
  2. MAP4K
  3. MAP4K4-IN-3

MAP4K4-IN-3 

Cat. No.: HY-125012
Handling Instructions

MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent.

For research use only. We do not sell to patients.

MAP4K4-IN-3 Chemical Structure

MAP4K4-IN-3 Chemical Structure

CAS No. : 1811510-58-3

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Description

MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1].

IC50 & Target[1]

MAP4K4

14.9 nM (IC50)

In Vitro

MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic agents[1].

In Vivo

Oral dosing in telemetered rats for 5 days with MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) results in a number of adverse effects. Substantial weight losses (7%) and body temperature increases (0.4°C) relative to controls are observed over the course of the study. For cardiovascular end points, maximal heart rate increases of 25 bpm, relative to controls, are induced by treatment with MAP4K4-IN-3[2].

Molecular Weight

297.74

Formula

C₁₅H₁₂ClN₅

CAS No.

1811510-58-3

SMILES

NC1=NC=C(C2=CC(C3=CC=C(Cl)C=C3)=C(N)N=C2)C=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MAP4K4-IN-3MAP4KMAPK Kinase Kinase KinaseMAP4K4antidiabeticInhibitorinhibitorinhibit

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