24 Results for "

menthol

" in MedChemExpress (MCE) Product Catalog:
Products (24)

24 Results for "menthol" in MCE Product Catalog:

9
9 Publications Verification
Cat. No.: HY-18662
CAS No.: 1254205-52-1
Target:  

TRP Channel

Research Areas:  

Neurological Disease Cancer

RQ-00203078 is a highly selective, potent and orally active TRPM8 antagonist with IC50s of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRPA1, TRPV4, or TRPM2 channels .
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5
5 Cited Publications
Cat. No.: HY-75161
CAS No.: 2216-51-5
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca 2+-permeable nonselective cation channel, to increase [Ca 2+]i . Antitumor activity .
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2
2 Cited Publications
Cat. No.: HY-108449
CAS No.: 68489-09-8
Purity:  99.13%
Synonyms: WS-12; AR-15512; AVX-012
Target:  

TRP Channel

Research Areas:  

Neurological Disease

Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .
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Cat. No.: HY-Y1683
CAS No.: 89-78-1
Synonyms: Racementhol
DL-Menthol (Racementhol) is an orally active, GABAaR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABAAR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production .
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Cat. No.: HY-W017277
CAS No.: 15356-60-2
Synonyms: D-menthol
(+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .
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Cat. No.: HY-115506
CAS No.: 1398583-31-7
Purity:  99.84%
Target:  

TRP Channel

Research Areas:  

Neurological Disease

PF-05105679, a chemical probe, is an orally active and selective TRPM8 antagonist with an IC50 of 103 nM. PF-05105679 has the potential for cold-related pain .
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Cat. No.: HY-N7132
CAS No.: 2623-23-6
Synonyms: L-Menthyl acetate
(-)-Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol and also a skin penetration enhancer for 5-aminolevulinic acid (ALA). (-)-Menthyl acetate exhibits strong ALA skin penetration-enhancing activity .
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Cat. No.: HY-75161R
CAS No.: 2216-51-5
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .
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Cat. No.: HY-122317
CAS No.: 79466-08-3
Purity:  95.0%
Target:  

Drug Metabolite

Research Areas:  

Others

Menthol glucuronide, a metabolite of Menthol (HY-N1369), is a plasma and urine biomarker of acute Menthol inhalation .
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Cat. No.: HY-W1008636
CAS No.: 3623-52-7
Isomenthol is a isomer of menthol with two stable gas-phase conformers. Isomenthol has gas-phase conformers proposed to be non-minty due to axial methyl or axial isopropyl groups .
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Cat. No.: HY-N1369S
CAS No.: 1217765-02-0
Menthol-d4 is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes .
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Cat. No.: HY-W683864
CAS No.: 16409-46-4
Target:  

Drug Intermediate

Research Areas:  

Others

Menthyl isovalerate is an ester formed by menthol and isovaleric acid. Menthyl isovalerate can be used as a food additive for flavor and fragrance .
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Cat. No.: HY-N7536
CAS No.: 510-22-5
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC50=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC50=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50=9 μM) and it shows noncompetitive inhibition against icilin (IC50=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana .
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Cat. No.: HY-108449S
Synonyms: WS-12-d3; AR-15512-d3; AVX-012-d3
Acoltremon-d3 (WS-12-d3) is the deuterium labeled Acoltremon (HY-108449). Acoltremon is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .
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Cat. No.: HY-N1369S1
CAS No.: 1335435-38-5
Menthol-d2 is deuterated labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes .
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Cat. No.: HY-W087943
CAS No.: 111-11-5
Methyl octanoate is an ester volatile compound with an odor activity value greater than 1. Methyl octanoate helps impart brandy-like and fruity characteristics to persimmon wine. Methyl octanoate has a strong odor of citrus holly, camphor and menthol. Methyl octanoate can serve as an early marker for grape infection by *Coniella vitis*. Methyl octanoate can be used in studies related to grape white rot .
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Cat. No.: HY-W017277R
CAS No.: 15356-60-2
Synonyms: D-menthol (Standard)
(+)-Menthol (Standard) is the analytical standard of (+)-Menthol. This product is intended for research and analytical applications. (+)-Menthol (D-Menthol) is one of the optical isomers of Menthol. (+)-Menthol can reduce the electrically evoked contractions of rat phrenic hemidiaphragm in vitro. Local anaesthetic activity. (+)-Menthol inhibits fungal growth and sporulation. (+)-Menthol can also inhibit the growth of Microcystis aeruginosa cells .
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Cat. No.: HY-Y1683R
CAS No.: 89-78-1
Synonyms: Racementhol (Standard)
DL-Menthol (Standard) is the analytical standard of DL-Menthol. This product is intended for research and analytical applications. DL-Menthol is a relative configuration of (-)-Menthol. DL-Menthol relates to the activation of GABAA receptor .
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Cat. No.: HY-W711474
CAS No.: 1450828-98-4
(-)-Menthol-d4 is the deuterium labeled (-)-Menthol (HY-75161). (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .
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Cat. No.: HY-W087207
CAS No.: 1091621-63-4
Target:  

Drug Derivative

Research Areas:  

Inflammation/Immunology

Loxoprofen L-menthol ester is a degradation product Loxoprofen sodium (HY-B0578A). Loxoprofen sodium is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties .
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