Acoltremon-d3
Based on 1 Customer Validation
Acoltremon-d3 (WS-12-d3) is the deuterium labeled Acoltremon (HY-108449). Acoltremon is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research.
For research use only. We do not sell to patients.
- Purity: 99.58%
- Formula: C18H24D3NO2
- Molecular Weight:292.43
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 68489-09-8
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Appearance Solid
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Molecular Weight 292.43
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Formula C18H24D3NO2
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Color White to off-white
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SMILES
O=C([C@@H]1C[C@@H](CC[C@H]1C(C)C)C)NC(C=C2)=CC=C2OC([2H])([2H])[2H]
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Synonyms
WS-12-d3; AR-15512-d3; AVX-012-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 16.67 mg/mL (57.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Beck B, et al. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium. 2007 Mar;41(3):285-94. [Content Brief]
[2]. Ma S, et al. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pak J Pharm Sci. 2008 Oct;21(4):370-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.4196 mL | 17.0981 mL | 34.1962 mL | 85.4905 mL |
| 5 mM | 0.6839 mL | 3.4196 mL | 6.8392 mL | 17.0981 mL | |
| 10 mM | 0.3420 mL | 1.7098 mL | 3.4196 mL | 8.5491 mL | |
| 15 mM | 0.2280 mL | 1.1399 mL | 2.2797 mL | 5.6994 mL | |
| 20 mM | 0.1710 mL | 0.8549 mL | 1.7098 mL | 4.2745 mL | |
| 25 mM | 0.1368 mL | 0.6839 mL | 1.3678 mL | 3.4196 mL | |
| 30 mM | 0.1140 mL | 0.5699 mL | 1.1399 mL | 2.8497 mL | |
| 40 mM | 0.0855 mL | 0.4275 mL | 0.8549 mL | 2.1373 mL | |
| 50 mM | 0.0684 mL | 0.3420 mL | 0.6839 mL | 1.7098 mL |
Acoltremon-d3 Related Classifications
HY-108449S Related Classifications
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