2. Others Neuronal Signaling Membrane Transporter/Ion Channel
  3. TRP Channel Isotope-Labeled Compounds
  4. Acoltremon-d3

Acoltremon-d3  (Synonyms: WS-12-d3; AR-15512-d3; AVX-012-d3)

Cat. No.: HY-108449S Purity: 99.58%
COA
SDS
Handling Instructions Technical Support

Acoltremon-d3 (WS-12-d3) is the deuterium labeled Acoltremon (HY-108449). Acoltremon is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research.

For research use only. We do not sell to patients.

Acoltremon-d<sub>3</sub>

Acoltremon-d3 Chemical Structure

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Acoltremon-d3:

Acoltremon-d3 Related Antibodies

Top Publications Citing Use of Products

View All TRP Channel Isoform Specific Products:

View All Isoforms
TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Acoltremon-d3 (WS-12-d3) is the deuterium labeled Acoltremon (HY-108449). Acoltremon is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research[1][2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acoltremon-d3 Related Antibodies
Molecular Weight

292.43

Formula

C18H24D3NO2
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1C[C@@H](CC[C@H]1C(C)C)C)NC(C=C2)=CC=C2OC([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (57.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4196 mL 17.0981 mL 34.1962 mL
5 mM 0.6839 mL 3.4196 mL 6.8392 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.58%

SDS (251 KB)

COA (247 KB) HNMR (221 KB) LCMS (101 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4196 mL 17.0981 mL 34.1962 mL 85.4905 mL
5 mM 0.6839 mL 3.4196 mL 6.8392 mL 17.0981 mL
10 mM 0.3420 mL 1.7098 mL 3.4196 mL 8.5491 mL
15 mM 0.2280 mL 1.1399 mL 2.2797 mL 5.6994 mL
20 mM 0.1710 mL 0.8549 mL 1.7098 mL 4.2745 mL
25 mM 0.1368 mL 0.6839 mL 1.3678 mL 3.4196 mL
30 mM 0.1140 mL 0.5699 mL 1.1399 mL 2.8497 mL
40 mM 0.0855 mL 0.4275 mL 0.8549 mL 2.1373 mL
50 mM 0.0684 mL 0.3420 mL 0.6839 mL 1.7098 mL
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Acoltremon-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acoltremon-d3WS-12-d3 AR-15512-d3 AVX-012-d3TRP ChannelIsotope-Labeled CompoundsTransient receptor potential channelsInhibitorinhibitorinhibit

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