68489-09-8
68489-09-8
Chemical Structure
Acoltremon
Synonym(s): WS-12; AR-15512; AVX-012
- CAS. Nr.: 68489-09-8
- Formula:C18H27NO2
- Molecular Weight:289.41
IUPAC Name: (1R,2S,5R)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide
InChIKey: HNSGVPAAXJJOPQ-XOKHGSTOSA-N
SMILES: O=C([C@H]1[C@H](C(C)C)CC[C@@H](C)C1)NC2=CC=C(OC)C=C2
Biological Activity: Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Acoltremon | 99.13% | Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research. | ||||||||||||||||||||
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Acoltremon (Standard) | ≥98% | Acoltremon (Standard) is the analytical standard of Acoltremon (HY-108449). This product is intended for research and analytical applications. Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research. | ||||||||||||||||||||
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Acoltremon-d3 | 99.58% | Acoltremon-d3 (WS-12-d3) is the deuterium labeled Acoltremon (HY-108449). Acoltremon is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research. | ||||||||||||||||||||
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References
- [1]. Beck B, et al. Prospects for prostate cancer imaging and therapy using high-affinity TRPM8 activators. Cell Calcium. 2007 Mar;41(3):285-94. [Content Brief]
- [2]. Ma S, et al. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pak J Pharm Sci. 2008 Oct;21(4):370-8. [Content Brief]
