89-78-1
Chemical Structure
DL-Menthol
Synonym(s): Racementhol
- CAS No.: 89-78-1
- Formula:C10H20O
- Molecular Weight:156.27
InChIKey: NOOLISFMXDJSKH-KXUCPTDWSA-N
SMILES: C[C@H]1C[C@@H](O)[C@H](C(C)C)CC1
Biological Activity: DL-Menthol (Racementhol) is an orally active, GABAaR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABAAR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production[1][2][3].
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DL-Menthol | 98.0% | DL-Menthol (Racementhol) is an orally active, GABAaR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABAAR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production. | ||||||||||||||||||||
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DL-Menthol (Standard) | ≥98% | DL-Menthol (Standard) is the analytical standard of DL-Menthol. This product is intended for research and analytical applications. DL-Menthol is a relative configuration of (-)-Menthol. DL-Menthol relates to the activation of GABAA receptor. | ||||||||||||||||||||
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- [1]. Kozlovich S, et al. Role of l- and d-Menthol in the Glucuronidation and Detoxification of the Major Lung Carcinogen, NNAL. Drug Metab Dispos. 2019 Dec;47(12):1388-1396. [Content Brief]
- [2]. Kasai, Masanori, et al. Menthol induces surgical anesthesia and rapid movement in fishes. Open Neuroscience Journal 8 (2014): 1-8.
- [3]. Jia-yu Cai, et al. Menthol-modified paclitaxel multifunctional cationic liposomes cross the blood-brain barrier and target glioma stem cells for treatment of glioblastoma. Journal of Drug Delivery Science and Technology. Volume 93, March 2024, 105387.
Keywords
