510-22-5
Chemical Structure
Voacangine
- CAS No.: 510-22-5
- Formula:C22H28N2O3
- Molecular Weight:368.47
IUPAC Name: methyl (6S,6aS,7S,9R,11S)-7-ethyl-2-methoxy-7,8,9,10,12,13-hexahydro-5H-6,9-methanopyrido[1',2':1,2]azepino[4,5-b]indole-6(6aH)-carboxylate
InChIKey: MMAYTCMMKJYIAM-PHKAQXKASA-N
SMILES: COC([C@]12[C@@]3([H])[N@@](CCC4=C2NC5=CC=C(OC)C=C54)C[C@@](C[C@@H]3CC)([H])C1)=O
Biological Activity: Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC50=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC50=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50=9 μM) and it shows noncompetitive inhibition against icilin (IC50=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Voacangine | 98.78% | Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC50=8 μM). Voacangine competitively blockes capsaicin binding to TRPV1 (IC50=50 μM). Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50=9 μM) and it shows noncompetitive inhibition against icilin (IC50=7 μM). Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana. | ||||||||||||||||||||
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Keywords
