2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. MGAT2-IN-7

MGAT2-IN-7 (compound 27Q) is a substituted benzenesulfonamide compound and also a monoacylglycerol acyltransferase 2 (MGAT2) inhibitor. MGAT2-IN-7 is used for research on obesity and metabolic dysfunction-associated steatotic liver disease (MASLD).

For research use only. We do not sell to patients.

MGAT2-IN-7

MGAT2-IN-7 Chemical Structure

CAS No. : 3115123-06-0

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MGAT2-IN-7 Related Antibodies

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ACAT1 ACAT2 MGAT2 ACAT DGAT1 DGAT2

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Description

MGAT2-IN-7 (compound 27Q) is a substituted benzenesulfonamide compound and also a monoacylglycerol acyltransferase 2 (MGAT2) inhibitor. MGAT2-IN-7 is used for research on obesity and metabolic dysfunction-associated steatotic liver disease (MASLD)[1].

In Vitro

MGAT2-IN-7 (compound 27Q) (0.1-10 μM; 45 h) potently inhibits human monacylglycerol acyltransferase 2 with an IC50 of <1 μM in an in vitro thiol-fluorescence enzyme assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MGAT2-IN-7 Related Antibodies
In Vivo

MGAT2-IN-7 (compound 27Q) (15-50 mg/kg; p.o.; daily; 7 days) induces dose-dependent weight loss and reduced food intake in diet-induced obese mice, with 50 mg/kg (p.o., daily for 7 days) causing a 6.8% body weight reduction[1].
MGAT2-IN-7 (27Q) (50 mg/kg; p.o.; daily; 22 days) synergistically enhances weight loss and food intake reduction when combined with GLP-1 receptor agonists in diet-induced obese mice at a dose of 50 mg/kg (p.o., daily for 22 days), with the body weight reduction effects measured at 17 days[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 16 weeks old, diet-induced obese)[1]
Dosage: 15 mg/kg; 50 mg/kg
Administration: p.o.; daily; 7 days
Result: Reduced average body weight by 1.39 g (3.6%) over 7 days, with 10% less 24-hour food intake and 9% less 7-day cumulative food.
Reduced average body weight by 2.5 g (6.8%) over 7 days, with 17% less 24-hour food intake and 20% less 7-day cumulative food.
Animal Model: C57BL/6J (male, diet-induced obese)[1]
Dosage: 50 mg/kg
Administration: p.o.; daily; 22 days
Result: Increased body weight reduction from -17.8% (tirzepatide alone) to -38% at 17 days and reduced cumulative food intake by 84% relative to vehicle controls (a 4-fold additional reduction over tirzepatide alone) when combined with maximum dose tirzepatide.
Increased body weight reduction from -32% (semaglutide alone) to -74.3% at 17 days and reduced cumulative food intake by 77% relative to vehicle controls (a 3.3-fold additional reduction over semaglutide alone) when combined with maximum dose semaglutide.
All differences were statistically significant.
Molecular Weight

629.65

Formula

C31H30F3N3O6S
CAS No.
SMILES

CC1=CC=C(C(C2=CC=C(C=N2)COC3CCN(CC3)C4=CC=C(C=C4)OC(F)(F)F)=C1)S(=O)(NC(C5=CC=C(O5)C)=O)=O
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Purity & Documentation
References
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MGAT2-IN-7 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MGAT2-IN-73115123-06-0AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferasemetabolic dysfunction-associated steatotic liver diseasehuman monacylglycerol acyltransferase 2GLP-1 receptor agonistsobesitymonacylglycerol acyltransferase 2diet-induced obese miceInhibitorinhibitorinhibit

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