2. GPCR/G Protein
  3. Leukotriene Receptor
  4. Moxilubant hydrochloride

Moxilubant hydrochloride  (Synonyms: CGS 25019C hydrochloride)

Cat. No.: HY-106929B
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Moxilubant (CGS 25019C) hydrochloride is an orally active BLT1 antagonist. Moxilubant hydrochloride inhibits LTB4 signaling with a potency of 2-4 nM. Moxilubant hydrochloride blocks LTB4-induced neutrophil functions. Moxilubant hydrochloride inhibits ear edema and neutrophil infiltration in mice. Moxilubant hydrochloride can be used in research related to chronic obstructive pulmonary disease.

For research use only. We do not sell to patients.

Moxilubant hydrochloride

Moxilubant hydrochloride Chemical Structure

CAS No. : 146957-32-6

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Moxilubant hydrochloride Related Antibodies

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

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Description

Moxilubant (CGS 25019C) hydrochloride is an orally active BLT1 antagonist. Moxilubant hydrochloride inhibits LTB4 signaling with a potency of 2-4 nM. Moxilubant hydrochloride blocks LTB4-induced neutrophil functions. Moxilubant hydrochloride inhibits ear edema and neutrophil infiltration in mice. Moxilubant hydrochloride can be used in research related to chronic obstructive pulmonary disease[1][2].

In Vivo

Moxilubant (0.1-10 mg/kg; p.o.; single administration) hydrochloride dose-dependently inhibits arachidonic acid (HY-109590)-induced ear edema and neutrophil infiltration in mice[1].
Moxilubant (oral administration; single dose) hydrochloride dose-dependently inhibits LTB4-induced neutropenia in rats, with ED50 values ranging from 2 mg/kg to 11 mg/kg within 1 to 18 hours post-administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/CBYJ mice treated Arachidonic acid[1]
Dosage: 0.1 mg/kg; 1.0 mg/kg; 3.0 mg/kg; 10.0 mg/kg
Administration: p.o.; single dose
Result: Caused a 19% reduction in edema and a 4% change in MPO activity at 0.1 mg/kg (1.5 hours post-dose).
Caused a 41% reduction in edema and a 39% reduction in MPO activity at 1.0 mg/kg (1.5 hours post-dose).
Caused a 65% reduction in edema and a 76% reduction in MPO activity at 3.0 mg/kg (1.5 hours post-dose).
Reached an ED50 of 1.4 mg/kg for edema inhibition and 1.2 mg/kg for MPO activity inhibition (1.5 hours post-dose).
Caused a 24% reduction in edema and a 3% increase in MPO activity at 1.0 mg/kg (18 hours post-dose).
Caused a 47% reduction in edema and a 25% reduction in MPO activity at 3.0 mg/kg (18 hours post-dose).
Caused a 55% reduction in edema and a 58% reduction in MPO activity at 10.0 mg/kg (18 hours post-dose).
Reached an ED50 of 5.7 mg/kg for edema inhibition and 7.7 mg/kg for MPO activity inhibition (18 hours post-dose).
Molecular Weight

492.05

Formula

C26H38ClN3O4
CAS No.
SMILES

[H]Cl.CC(C)N(C(C)C)C(C1=CC(OC)=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Moxilubant hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moxilubant146957-32-6CGS 25019CLeukotriene Receptorcalcium influxratLeukotriene B4copdCD11bneutrophilBALB/CBYJ mousearachidonic acidmyeloperoxidaseLTB4 receptorInhibitorinhibitorinhibit

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