Moxilubant hydrochloride
Based on 1 publication(s) in Google Scholar
Moxilubant (CGS 25019C) hydrochloride is an orally active BLT1 antagonist. Moxilubant hydrochloride inhibits LTB4 signaling with a potency of 2-4 nM. Moxilubant hydrochloride blocks LTB4-induced neutrophil functions. Moxilubant hydrochloride inhibits ear edema and neutrophil infiltration in mice. Moxilubant hydrochloride can be used in research related to chronic obstructive pulmonary disease.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 146957-32-6
- 分子式: C26H38ClN3O4
- 分子量:492.05
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Other In-stock Forms of Moxilubant hydrochloride
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Moxilubant hydrochloride
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生物活性
製品説明
体内実験
Moxilubant (oral administration; single dose) hydrochloride dose-dependently inhibits LTB4-induced neutropenia in rats, with ED50 values ranging from 2 mg/kg to 11 mg/kg within 1 to 18 hours post-administration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/CBYJ mice treated Arachidonic acid[1]
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Dosage:0.1 mg/kg; 1.0 mg/kg; 3.0 mg/kg; 10.0 mg/kg
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Administration:p.o.; single dose
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Result:Caused a 19% reduction in edema and a 4% change in MPO activity at 0.1 mg/kg (1.5 hours post-dose).
Caused a 41% reduction in edema and a 39% reduction in MPO activity at 1.0 mg/kg (1.5 hours post-dose).
Caused a 65% reduction in edema and a 76% reduction in MPO activity at 3.0 mg/kg (1.5 hours post-dose).
Reached an ED50 of 1.4 mg/kg for edema inhibition and 1.2 mg/kg for MPO activity inhibition (1.5 hours post-dose).
Caused a 24% reduction in edema and a 3% increase in MPO activity at 1.0 mg/kg (18 hours post-dose).
Caused a 47% reduction in edema and a 25% reduction in MPO activity at 3.0 mg/kg (18 hours post-dose).
Caused a 55% reduction in edema and a 58% reduction in MPO activity at 10.0 mg/kg (18 hours post-dose).
Reached an ED50 of 5.7 mg/kg for edema inhibition and 7.7 mg/kg for MPO activity inhibition (18 hours post-dose).
化学情報
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CAS 番号 146957-32-6
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分子量 492.05
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分子式 C26H38ClN3O4
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SMILES
[H]Cl.CC(C)N(C(C)C)C(C1=CC(OC)=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)=O
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別名
CGS 25019C hydrochloride
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Med Chem
Discovery of Chromone Derivatives as Selective BLT1 Inhibitors for Alleviating Acute Lung Injury and Sepsis. [Abstract]2026 Feb 26;69(4):4361-4390. PMID: 41696851
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Moxilubant hydrochloride 関連分類
HY-106929B 関連分類
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