1. PI3K/Akt/mTOR
  2. mTOR
  3. mTOR inhibitor-7

mTOR inhibitor-7 

Cat. No.: HY-136660
Handling Instructions

mTOR inhibitor-7 is an orally available, and brain-penetrant mTOR inhibitor extracted from patent WO2017198346A1, compound example 44, has an IC50 of 5 nM for mTOR. mTOR inhibitor-7 can be used for the research of neurological disorder.

For research use only. We do not sell to patients.

mTOR inhibitor-7 Chemical Structure

mTOR inhibitor-7 Chemical Structure

CAS No. : 1927857-98-4

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Description

mTOR inhibitor-7 is an orally available, and brain-penetrant mTOR inhibitor extracted from patent WO2017198346A1, compound example 44, has an IC50 of 5 nM for mTOR. mTOR inhibitor-7 can be used for the research of neurological disorder[1].

IC50 & Target

IC50: 5 nM (mTOR)[1]

In Vitro

mTOR inhibitor-7 (0.04-5 μΜ; 1 hour) has IC50s of 197 nM and 87 nM for pPKB S473 and pS6 S235/S236, respectively, in-cell western blot. S6 kinase (S6K), S6 ribosomal protein (S6rP) and 4E-binding protein (4E-BP) are prominent downstream effectors of mTOR[1].

Western Blot Analysis[1]

Cell Line: A2058 cells
Concentration: 0.04 μΜ, 0.08 μΜ, 0.155 μΜ, 0.3125 μΜ, 0.625 μΜ, 1.25 μΜ, 5 μΜ
Incubation Time: 1 hour
Result: Inhibited mTOR in cell.
Molecular Weight

435.47

Formula

C₂₀H₂₇F₂N₇O₂

CAS No.

1927857-98-4

SMILES

NC1=NC=C(C2=NC(N3[[email protected]](C)COC[[email protected]@H]3C)=NC(N4[[email protected]](C)COCC4)=N2)C(C(F)F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

mTOR inhibitor-7mTOR inhibitor7mTOR inhibitor 7mTORMammalian target of Rapamycinneurologicaldisorderbrain-penetrantInhibitorinhibitorinhibit

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mTOR inhibitor-7
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