81 Results for "

SMA

" in MedChemExpress (MCE) Product Catalog:
Products (81)

81 Results for "SMA" in MCE Product Catalog:

16
Branaplam
Branaplam
0 Images
16 Publications Verification
Cat. No.: HY-19620
CAS No.: 1562338-42-4
Synonyms: LMI070; NVS-SM1
Target:  

DNA/RNA Synthesis Potassium Channel

Research Areas:  

Cancer

Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model .
16
Branaplam hydrochloride
Branaplam hydrochloride
0 Images
16 Publications Verification
Cat. No.: HY-19620A
CAS No.: 1562338-39-9
Synonyms: LMI070 hydrochloride; NVS-SM1 hydrochloride
Target:  

DNA/RNA Synthesis Potassium Channel

Research Areas:  

Cancer

Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model .
5
Nusinersen
Nusinersen
0 Images
5 Cited Publications
Cat. No.: HY-112980
CAS No.: 1258984-36-9
Purity:  97.79%
Target:  

DNA/RNA Synthesis

Research Areas:  

Neurological Disease

Nusinersen is an antisense oligonucleotide active molecule. Nusinersen modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen improves spinal muscular atrophy .
5
Nusinersen sodium
Nusinersen sodium
0 Images
5 Cited Publications
Cat. No.: HY-112980A
Purity:  98.91%
Target:  

DNA/RNA Synthesis

Research Areas:  

Neurological Disease

Nusinersen sodium is an antisense oligonucleotide active molecule. Nusinersen sodium modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length SMN protein. Nusinersen sodium improves spinal muscular atrophy .
4
AA147
AA147
0 Images
4 Cited Publications
Cat. No.: HY-124293
CAS No.: 393121-74-9
Purity:  99.81%
Target:  

ATF6 Reactive Oxygen Species (ROS)

Research Areas:  

Neurological Disease Metabolic Disease

AA147 is a endoplasmic reticulum (ER) proteostasis regulator. AA147 promotes protection against oxidative damage in neuronal cells and prevents endothelial barrier dysfunction by activating ATF6 arm (selectively) of the unfolded protein response (UPR) and the NRF2 oxidative stress response. AA147 can rebalances XBP1s expression in vivo, and also induces survival motor neuron (SMN) expression and spinal motorneuron (MN) protection .
4
alpha smooth muscle Actin Antibody (YA627)
alpha smooth muscle Actin Antibody (YA627)
0 Images
4 Cited Publications
Cat. No.: HY-P80484
Synonyms: alpha sarcomeric Actin; alpha smooth muscle Actin; Actin alpha; ASMA; ASM-A; alpha-SMA; alpha SMA; AAT6; ACTA2; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; ACTSA; ACTVS; Alpha 2 actin; Alpha-actin 2; Cell growth inhibiting gene 46 protein; Growth inhibiting gene 46; ACTA_HUMAN; Actin alpha 2 smooth muscle aorta; Actin aortic smooth muscle; Actin, aortic smooth muscle; Alpha 2 actin; Alpha actin 2; Alpha cardiac actin; Alpha-actin 2; Alpha-actin-2; Cell growth inhibiting gene 46 protein; Cell growth-inhibiting gene 46 protein; Growth inhibiting gene 46; MYMY5 α-Smooth Muscle Actin; α Smooth Muscle Actin;

Host:  

Rabbit

Application:  

WB, IHC-P, FC, IP

Reactivity:  

Human, Mouse

3
TGFβ1-IN-1
TGFβ1-IN-1
0 Images
3 Cited Publications
Cat. No.: HY-151427
CAS No.: 2348795-14-0
Purity:  99.47%
Target:  

TGF-β Receptor

Research Areas:  

Inflammation/Immunology

TGFβ1-IN-1 (compound 42) is a potent, orally active TGF-β1 inhibitor. TGFβ1-IN-1 inhibits the upregulation of TGF-β1-induced fibrosis markers (α-SMA and fibronectin) and can be used in liver fibrosis disease studies .
1
(Rac)-Indoximod
(Rac)-Indoximod
0 Images
1 Cited Publications
Cat. No.: HY-133897
CAS No.: 26988-72-7
Purity:  99.18%
Synonyms: 1-Methyl-DL-tryptophan; (Rac)-NLG-8189
Target:  

Indoleamine 2,3-Dioxygenase (IDO) Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes .
1
FXR agonist 3
FXR agonist 3
0 Images
1 Cited Publications
Cat. No.: HY-151932
CAS No.: 3037847-72-3
Purity:  95.94%
Target:  

FXR

Research Areas:  

Inflammation/Immunology

FXR agonist 3 is an anti-NASH agent, acting by activating FXR. FXR agonist 3 inhibits COL1A1, TGF-β1, α-SMA and TIMP1 expression with anti-fibrogenic activity. FXR agonist 3 significantly reduces liver steatosis and inflammation, improves liver fibrosis level .
1
TGFβ-IN-2
TGFβ-IN-2
0 Images
1 Cited Publications
Cat. No.: HY-146434
CAS No.: 2387678-02-4
Purity:  99.37%
Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

TGFβ-IN-2 is an orally active TGF-β inhibitor. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 demonstrates excellent anti-fibrotic efficacy in Bleomycin (HY-108345)-induced pulmonary fibrosis model. TGFβ-IN-2 can be used for the study of pulmonary fibrosis .
NCGC00685960
NCGC00685960
0 Images
Cat. No.: HY-175603
CAS No.: 3091000-99-3
Target:  

Amine N-methyltransferase

Research Areas:  

Cancer

NCGC00685960 is a Nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 <10  nM. NCGC00685960 has potent antitumor activity. NCGC00685960 increases H3K27 trimethylation levels in ovarian cancer cells and inhibits α-SMA expression in NNMT-expressing ovarian fibroblasts. NCGC00685960 reduces 1-MNA levels, reverses SAM and H3K27 hypomethylation and significantly impairs collagen contractility in cancer-associated fibroblasts (CAFs). NCGC00685960 can be used for cancers research, such as ovarian cancer, breast cancer, colon cancer .
Taldefgrobep alfa
Taldefgrobep alfa
0 Images
Cat. No.: HY-P99518
CAS No.: 1580555-26-5
Synonyms: BMS 986089; RG 6206; RO 7239361; BHV2000

Target:  

TGF-beta/Smad

Research Areas:  

Others

Taldefgrobep alfa (BMS 986089; RG 6206; RO 7239361) is a protein that blocks myostatin. Taldefgrobep alfa is a fusion protein composed of a human IgG1-Fc domain and Adnectin domain. Taldefgrobep alfa can be used for spinal muscular atrophy (SMA) research .
MF-DH-300
MF-DH-300
0 Images
Cat. No.: HY-176803
CAS No.: 2673403-86-4
Target:  

15-PGDH

Research Areas:  

Neurological Disease

MF-DH-300 is a 15-PGDH inhibitor that can be applicable to the research of muscle disorders such as spinal muscular atrophy (SMA).
Methyl cholate
Methyl cholate
0 Images
Cat. No.: HY-107830
CAS No.: 1448-36-8
Purity:  99.81%
Category:  

Microorganisms Metabolic Disease Disease Research Fields Steroids

Target:  

Endogenous Metabolite Collagen

Methyl cholate is a bile acid analog and a specific inhibitor of TcdB toxin from Clostridioides difficile. Methyl cholate exerts a stronger selective inhibitory effect on TcdB than on TcdA. Methyl cholate induces conformational stabilization by binding to a unique site of TcdB, thereby blocking the binding of the toxin to host receptors and its self-processing process. Methyl cholate effectively protects human fibroblasts from TcdB-induced cytopathic effects. Methyl cholate exhibits dose-dependent anti-hepatic fibrosis activity in both cellular and zebrafish models, and significantly reduces the expression levels of α-SMA and COL-I. Methyl cholate is suitable for in-depth research in the fields of Clostridioides difficile infection and hepatic fibrosis .
Armepavine
Armepavine
0 Images
Cat. No.: HY-N6857
CAS No.: 524-20-9
Category:  

Plants Nymphaeaceae Alkaloids other families Monophenols Phenols Nelumbo nucifera Gaertn. Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology

Target:  

AP-1 NF-κB p38 MAPK ERK JNK

Armepavine, found in Nelumbo nucifera, is an orally active NF-κB inhibitor. Armepavine attenuates expression of p-p65, α-SMA, p-JNK1/2, p-ERK1/2, p-p38α stimulated by TNF-α and LPS. Armepavine suppresses NF-κB nuclear translocation, IκBα phosphorylation, and collagen deposition. Armepavine can be used for the research of hepatic fibrosis and leukemia .
SMN-C3
SMN-C3
0 Images
Cat. No.: HY-112633
CAS No.: 1449597-34-5
Purity:  99.53%
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

SMN-C3 is an orally active SMN2 splicing modulator and has the potential to treat spinal muscular atrophy (SMA).
SMN-C2
SMN-C2
0 Images
Cat. No.: HY-124648
CAS No.: 1446311-56-3
Purity:  98.85%
Target:  

DNA/RNA Synthesis

Research Areas:  

Inflammation/Immunology

SMN-C2, an analog of RG-7916, is a selective modulator of SMN2 gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element binding protein 1 (FUBP1) and KH-spliced RNA binding Protein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research .
NVS-SM2
NVS-SM2
0 Images
Cat. No.: HY-111520
CAS No.: 1562333-92-9
Purity:  99.15%
Target:  

DNA/RNA Synthesis

Research Areas:  

Neurological Disease

NVS-SM2 is a potent, orally active and brain-penetrant SMN2 splicing enhancer with an EC50 of 2 nM for SMN. NVS-SM2 enhances U1-pre-mRNA association. NVS-SM2 promotes exon 7 inclusion and restores normal survival motor neuron (SMN) protein expression. NVS-SM2 can be used for spinal muscular atrophy (SMA) research .
Methylophiopogonone A
Methylophiopogonone A
0 Images
Cat. No.: HY-N2441
CAS No.: 74805-90-6
Category:  

Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Flavonoids Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Other Flavonoids

Target:  

NO Synthase Collagen p38 MAPK

Methylophiopogonone A is a homoisoflavonoid compound found in the tuberous roots of Ophiopogon japonicus. Methylophiopogonone A inhibits lipopolysaccharide-induced NO production in mouse microglia with an IC50 of 19.2 μM. Methylophiopogonone A blocks the proliferation of LX-2 hepatic stellate cells and downregulates TGF-β1-induced expressions of type I collagen and α-SMA. Methylophiopogonone A blocks RELA/EGFR-mediated hepatic stellate cell activation, inhibits the MAPK12 pathway to reduce extracellular matrix accumulation, and simultaneously suppresses inflammatory signal transduction. Methylophiopogonone A can be used in studies related to chronic hepatitis B-associated hepatic fibrosis and neuroinflammation .
TRV055
TRV055
0 Images
Cat. No.: HY-P3136
CAS No.: 25849-90-5
Synonyms: TRV120055
Target:  

Angiotensin Receptor ERK

Research Areas:  

Cardiovascular Disease

TRV055 (TRV120055) is a G protein-biased agonist of angiotensin II type 1 receptors (AT1Rs). TRV120055 induces fibroblast proliferation, overexpression of collagen I and α-SMA, and stress fibre formation in human cardiac fibroblasts. TRV055 activates AT1 receptor/Gαq-mediated signaling pathways, upregulates TGF-β1 and p-ERK1/2. TRV055 induces collagen secretion in adult rat myofibroblasts at a level comparable to Ang II. TRV055 can be used to study the role of G protein-biased signaling of AT1Rs in regulating fibrotic responses [1]
Assay Types