3091000-99-3
Chemical Structure
NCGC00685960
- CAS No.: 3091000-99-3
- Formula:C24H32ClN5O2
- Molecular Weight:458.00
IUPAC Name: (S)-8-(3-(1-(2-cyclohexylethyl)piperidin-3-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)quinolin-2(1H)-one hydrochloride
InChIKey: LBZRHGUGCNPMLK-FYZYNONXSA-N
SMILES: O=C1NC2=C(C=CC=C2N3N=C([C@@H]4CN(CCC5CCCCC5)CCC4)NC3=O)C=C1.Cl
Biological Activity: NCGC00685960 is a Nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 <10 nM. NCGC00685960 has potent antitumor activity. NCGC00685960 increases H3K27 trimethylation levels in ovarian cancer cells and inhibits α-SMA expression in NNMT-expressing ovarian fibroblasts. NCGC00685960 reduces 1-MNA levels, reverses SAM and H3K27 hypomethylation and significantly impairs collagen contractility in cancer-associated fibroblasts (CAFs). NCGC00685960 can be used for cancers research, such as ovarian cancer, breast cancer, colon cancer[1].
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NCGC00685960 | 99.97% | NCGC00685960 is a Nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 <10 nM. NCGC00685960 has potent antitumor activity. NCGC00685960 increases H3K27 trimethylation levels in ovarian cancer cells and inhibits α-SMA expression in NNMT-expressing ovarian fibroblasts. NCGC00685960 reduces 1-MNA levels, reverses SAM and H3K27 hypomethylation and significantly impairs collagen contractility in cancer-associated fibroblasts (CAFs). NCGC00685960 can be used for cancers research, such as ovarian cancer, breast cancer, colon cancer. | ||||||||||||||||||||
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