STK189682
STK189682 is an ATPase inhibitor targeting MDA5, LGP2 and DDX1, with IC50 values of 7 μM, 7 μM and 5 μM, respectively. STK189682 binds to the MDA5-ATP complex in an ATP-noncompetitive manner and does not compete with RNA.
For research use only. We do not sell to patients.
- CAS No.: 765922-18-7
- Formula: C21H16N4O4S2
- Molecular Weight:452.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
STK189682 potently inhibits the ATPase activities of recombinant MDA5 (IC50 = 7 μM), LGP2 (IC50 = 7 μM) and DDX1 (IC50 = 5 μM)[1].
STK189682 is an ATP-uncompetitive inhibitor of recombinant MDA5, which is evidenced by the observation that its IC50 value decreases as ATP concentration increases[1].
STK189682 does not compete with RNA for binding to recombinant MDA5, as the IC50 value remains unchanged with increasing RNA concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 765922-18-7
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Molecular Weight 452.51
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Formula C21H16N4O4S2
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SMILES
O=C(C1=CC=C(NC2=NC(C3=C(C)N=C(NC(C4=CC=CC=C4)=O)S3)=CS2)C=C1O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STK189682 Related Classifications
HY-187308 Related Classifications
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