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Odevixibat (Synonyms: A4250)

Cat. No.: HY-109120
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Odevixibat (A4250) is a potent, selective and orally active inhibitor of the ileal bile acid transporter (IBAT). Odevixibat (A4250)decreases cholestatic liver and bile duct injury in mice model. Odevixibat (A4250) has the potential for the treatment of primary biliary cirrhosis.

For research use only. We do not sell to patients.

Odevixibat Chemical Structure

Odevixibat Chemical Structure

CAS No. : 501692-44-0

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Description

Odevixibat (A4250) is a potent, selective and orally active inhibitor of the ileal bile acid transporter (IBAT). Odevixibat (A4250)decreases cholestatic liver and bile duct injury in mice model. Odevixibat (A4250) has the potential for the treatment of primary biliary cirrhosis[1].

IC50 & Target

IC50: IBAT[1]

In Vivo

Odevixibat (A4250)(0.01% (w/w) in chow diet; 4 weeks) improves sclerosing cholangitis and significantly reduces serum alanine aminotransferase, alkaline phosphatase and BAs levels, hepatic expression of pro-inflammatory and pro-fibrogenic genes and bile duct proliferation in Mdr2-/- mice[1].
In addition, Odevixibat (A4250) significantly reduces bile flow and biliary BA output, which correlates with reduced bsep transcription, while Ntcp and Cyp7a1 are induced[1].

Animal Model: Eight week old Mdr2-/- (Abcb4-/-) mice (model of cholestatic liver injury and sclerosing cholangitis)[1]
Dosage: 0.01% (w/w) in chow diet
Administration: 4 weeks
Result: Decreased cholestatic liver and bile duct injury in mice model.
Clinical Trial
Molecular Weight

740.93

Formula

C₃₇H₄₈N₄O₈S₂

CAS No.

501692-44-0

SMILES

CC[[email protected]](NC([[email protected]](NC(COC1=C(SC)C=C(C2=C1)N(C3=CC=CC=C3)CC(CCCC)(CCCC)NS2(=O)=O)=O)C4=CC=C(O)C=C4)=O)C(O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

OdevixibatA4250A 4250A-4250Othersprimary biliarycirrhosisIBAT cholestatic liverbile duct injuryInhibitorinhibitorinhibit

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Odevixibat
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HY-109120
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