1. Anti-infection
    Neuronal Signaling
  2. Fungal
    AChE
  3. Penconazole

Penconazole 

Cat. No.: HY-135761
Handling Instructions

Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.

For research use only. We do not sell to patients.

Penconazole Chemical Structure

Penconazole Chemical Structure

CAS No. : 66246-88-6

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Description

Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[1][2].

In Vivo

Penconazole (67 mg/kg; i.p.; every 2 days during 9 days) induces oxidative stress in rat cerebrum and cerebellum tissues[2].
Penconazole has the ability to induce oxidative damage in the brain of adult rats, as evidenced by an increase of lipid peroxidation and protein oxidation, in addition to the perturbations in the enzymatic and nonenzymatic antioxidant status. Penconazole also affects the cholinergic system, activities of membrane-bound ATPases, and brain histoarchitecture. Penconazole is a potential neurotoxicant pesticide that exerts its neurotoxic effects via the generation of oxidative stress. Penconazole causes a significant inhibition of AChE activity in the cerebrum (11%) and cerebellum (25%) of adult rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Twelve male Wistar rats[2]
Dosage: 67 mg/kg
Administration: I.p.; every 2 days during 9 days
Result: A significant increase was obtained in the absolute and relative weights of the cerebrum and cerebellum, respectively.
Molecular Weight

284.18

Formula

C₁₃H₁₅Cl₂N₃

CAS No.

66246-88-6

SMILES

CCCC(C1=CC=C(Cl)C=C1Cl)CN2N=CN=C2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PenconazoleFungalAChEAcetylcholinesteraseFungicideapplesgrapesvegetablessterolbiosynthesisantioxidantneurotoxicInhibitorinhibitorinhibit

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Penconazole
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HY-135761
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