Polythiazide 

Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity^[1][2][3].

Polythiazide (500 μM, 1 min) induces significant phototoxic NHIK 3025 cell death under Bluelight 2000 apparatus (Ex: 325 nM)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polythiazide (oral gavage, 10 mg/kg, daily for 5 days) Increases plasma cholesterol levels in Cholesterol-fed C57BL/cdJ mouse^[3].
Polythiazide (oral administration, 0.4 mg/kg) shows diuretic and saluretic effects in hypertensive dogs and rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

439.88

C₁₁H₁₃ClF₃N₃O₄S₃

346-18-9

Solid

White to off-white

O=S(C1=C(Cl)C=C(C2=C1)NC(CSCC(F)(F)F)N(C)S2(=O)=O)(N)=O

Room temperature in continental US; may vary elsewhere.

• [1]. A SCRIABINE, et al. Pharmacological studies with polythiazide, a new diuretic and antihypertensive agent. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:864-72.  [Content Brief]

  [2]. E Selvaag, et al. Phototoxicity due to sulphonamide derived oral antidiabetics and diuretics: investigations in a cell culture model. Photodermatol Photoimmunol Photomed. 1996 Feb;12(1):1-6.  [Content Brief]

  [3]. M N Krupp, et al. Effects of doxazosin and other antihypertensives on serum lipid levels and lipoprotein lipase in the C57BR/cdJ mouse. J Cardiovasc Pharmacol. 1989;13 Suppl 2:S11-8; discussion S18-9.  [Content Brief]