TECTB Protein, Human (HEK293, His)

TECTB Protein, a key non-collagenous component in the tectorial membrane of the inner ear, interacts with stereocilia bundles of sensory hair cells. In response to sound stimuli, stereocilia movement relative to the tectorial membrane causes fluctuations in hair cell membrane potential, transducing sound into electrical signals. TECTB may form homomeric or heteromeric filaments, associating with alpha-tectorin and interacting with CEACAM16, contributing to its role in the intricate architecture and sensory function of the tectorial membrane. TECTB Protein, Human (HEK293, His) is the recombinant human-derived TECTB protein, expressed by HEK293, with C-His labeled tag. The total length of TECTB Protein, Human (HEK293, His) is 287 a.a., with molecular weight of ~33.9 KDa.

TECTB Protein stands as one of the principal non-collagenous constituents within the tectorial membrane, an extracellular matrix situated in the inner ear that envelops the neuroepithelium of the cochlea and makes contact with the stereocilia bundles of specialized sensory hair cells. In response to sound stimuli, causing movement of these hair cells relative to the tectorial membrane, the stereocilia deflect, resulting in fluctuations in the membrane potential of hair cells. This process serves as a mechanism for the transduction of sound into electrical signals. TECTB may exhibit the formation of homomeric filaments through self-association or heteromeric filaments when associated with alpha-tectorin. Additionally, it interacts with CEACAM16, further contributing to its functional role in the intricate architecture and sensory function of the tectorial membrane.

Human

HEK293

C-His

Q96PL2/NP_478129.1 (K18-R304)

6975  [NCBI]

Approximately 33.9 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.