1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Ro15-4513

Ro15-4513 

Cat. No.: HY-103476 Purity: >98.0%
Handling Instructions

Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR). Ro15-4513 is a potent ethanol antagonist. Ro15-4513 has anti-anxiety effect.

For research use only. We do not sell to patients.

Ro15-4513 Chemical Structure

Ro15-4513 Chemical Structure

CAS No. : 91917-65-6

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 237 In-stock
Estimated Time of Arrival: December 31
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 330 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR)[1]. Ro15-4513 is a potent ethanol antagonist[2]. Ro15-4513 has anti-anxiety effect[3].

IC50 & Target

BZR[1]; ethanol[2];

In Vitro

Ro15-4513 usually acts as a partial inverse agonist at GABAA receptors, except an agonist for α4 and α6 subunit-containing ones[3].

In Vivo

Ro 15-4513 (i.p.; 3 mg/kg; 10 min before being tested) completely inhibits the ethanol-induced (1.8 g/kg) reduction in total locomotor activity and partly the reduction in rearing[2].
Ro 15-4513 (i.p.; 3 mg/kg; 15 min before administration of 1.5 g/kg ethanol) reverses ethanol-induced sedation in GABAA receptor δ subunit-deficient mice[2].

Animal Model: Male C57BL/6J mice[2]
Dosage: 3 mg/kg
Administration: I.p.; 10 min before being tested
Result: Completely inhibited the ethanol-induced reduction in total locomotor activity and partly the reduction in rearing.
Clinical Trial
Molecular Weight

326.31

Formula

C₁₅H₁₄N₆O₃

CAS No.

91917-65-6

SMILES

O=C(C1=C(CN2C)N(C=N1)C3=CC=C(N=[N+]=[N-])C=C3C2=O)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

References

Purity: >98.0%

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Keywords:

Ro15-4513GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorimidazobenzodiazepinonederivativepartialinverseagonistbenzodiazepinereceptorBZRethanol,GABAA,anti-anxietyInhibitorinhibitorinhibit

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Ro15-4513
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