6 Results for "

16E6

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "16E6" in MCE Product Catalog:

Cat. No.: HY-116073
CAS No.: 1113-41-3
Target:  

Acyltransferase

Research Areas:  

Infection Cancer

L-Penicillamine is an orally active serine palmitoyltransferase (SPT) inhibitor. L-Penicillamine inactivates the PLP cofactor by forming adducts, thereby inhibiting SPT activity and reducing sphingolipid biosynthesis. L-Penicillamine not only blocks tumor access to vitamin B6, but also stabilizes the human papillomavirus 16 E6 oncoprotein monomer and inhibits its polymerization, exhibiting a unique anticancer mechanism. L-Penicillamine effectively delays the growth of Sarcoma-180, induces tumor necrosis and prolongs survival (though long-term use may lead to Pyridoxine (HY-B1328) deficiency and weight loss) .
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Cat. No.: HY-P10428
Target:  

HPV

Research Areas:  

Infection

E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture .
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Cat. No.: HY-P89419

Host:  

Rabbit

Application:  

WB, IHC-P, IHC-F, FC, IF-Tissue

Reactivity:  

Virus

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Cat. No.: HY-P700914
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuHLA-A*0201 HPV16 E6 complex Protein
Species:  
Source:  
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Cat. No.: HY-P700915
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuHLA-A*0201 HPV16 E6 complex Protein
Species:  
Source:  
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Cat. No.: HY-N20712
CAS No.: 59632-76-7
Anisomelic acid is a human papillomavirus HPV16 E6 and HPV E7 depletor . Anisomelic acid directly interacts with HPV16 E6, promotes its ubiquitination and proteasomal degradation by recruiting E3 ubiquitin ligase, downregulates E6 and facilitates E7 degradation. Anisomelic acid induces endogenous mitochondrial apoptosis, activates caspase-3, causes cleavage of PARP, and triggers p53-independent endogenous apoptosis by depleting cIAP2. Anisomelic acid can be used in research related to HPV-positive cancers and cervical cancer .
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