59632-76-7
Chemical Structure
Anisomelic acid
- CAS No.: 59632-76-7
- Formula:C20H26O4
- Molecular Weight:330.42
InChIKey: SORYERHBQFTRIK-PUWPUPSASA-N
SMILES: O=C(/C1=C\CC/C(C)=C/[C@]([C@@](CC/C(C)=C/CC1)([H])C2=C)([H])OC2=O)O
Biological Activity: Anisomelic acid is a human papillomavirus HPV16 E6 and HPV E7 depletor. Anisomelic acid directly interacts with HPV16 E6, promotes its ubiquitination and proteasomal degradation by recruiting E3 ubiquitin ligase, downregulates E6 and facilitates E7 degradation. Anisomelic acid induces endogenous mitochondrial apoptosis, activates caspase-3, causes cleavage of PARP, and triggers p53-independent endogenous apoptosis by depleting cIAP2. Anisomelic acid can be used in research related to HPV-positive cancers and cervical cancer[1][2][3].
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Anisomelic acid | Anisomelic acid is a human papillomavirus HPV16 E6 and HPV E7 depletor. Anisomelic acid directly interacts with HPV16 E6, promotes its ubiquitination and proteasomal degradation by recruiting E3 ubiquitin ligase, downregulates E6 and facilitates E7 degradation. Anisomelic acid induces endogenous mitochondrial apoptosis, activates caspase-3, causes cleavage of PARP, and triggers p53-independent endogenous apoptosis by depleting cIAP2. Anisomelic acid can be used in research related to HPV-positive cancers and cervical cancer. | |||||||||||||||||||||
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- [1]. Santos Silva M, et al. Anisomelic acid promotes proteasomal degradation of HPV16 E6 via E3 ligase recruitment: A mass spectrometry-based interactome study. Journal of proteomics. 2026 Jan 06;322:105536. [Content Brief]
- [2]. Senthilkumar R, et al. Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect. Biomaterials science. 2015 Jan;3(1):103-11. [Content Brief]
- [3]. Paul P, et al. Novel action modality of the diterpenoid anisomelic acid causes depletion of E6 and E7 viral oncoproteins in HPV-transformed cervical carcinoma cells. Biochemical pharmacology. 2014 May 15;89(2):171-84. [Content Brief]
Keywords
